Methipred 8 mg (Tablet)

Unit Price: ৳ 11.00 (4 x 10: ৳ 440.00)

Strip Price: ৳ 110.00

Medicine Details

Category	Details
Generic	Methylprednisolone
Company	General pharmaceuticals ltd
Also available as	Methipred 2 mg tablet Methipred 4 mg tablet Methipred 16 mg tablet

Methipred Medication

A potent anti-inflammatory steroid with greater potency than Prednisolone and less tendency to induce sodium and water retention.

Treatment of endocrine disorders such as Adrenocortical Insufficiency
Management of rheumatic disorders like Rheumatoid Arthritis and Ankylosing Spondylitis
Use in collagen diseases and dermatologic conditions
Relief of allergy symptoms and ophthalmic diseases
Management of respiratory diseases and hematological disorders
Palliative care for neoplastic diseases
Management of edematous states and gastrointestinal diseases
Treatment of acute exacerbations of Multiple Sclerosis

Pharmacodynamic Properties:
- Potent anti-inflammatory agent
- Inhibits the immune system
- Affects kidney, fluid & electrolyte balance, lipid & protein metabolism, skeletal muscle, cardiovascular system, and more
Pharmacokinetic Properties:
- High oral bioavailability (82% to 89%)
- Rapid absorption with peak plasma concentration achieved in 1.5 to 2.3 hours
- Wide distribution in tissues including crossing the blood-brain and placental barriers
- Metabolized in the liver to inactive compounds
- Hemodialyzable

Usual Range: 2-48 mg daily in divided doses
Initial Dosage: 4-48 mg per day, adjusted based on disease severity
Maintenance Dosage: Gradual reduction to lowest effective dose
Treatment of Multiple Sclerosis: 160 mg daily for a week followed by 64 mg every other day for 1 month
Alternate-day Therapy: Regimen to minimize certain undesirable effects

Erythromycin, Clarithromycin, Phenobarbital, Phenytoin, Rifampin and Ketoconazole inhibit its metabolism
Estrogens can increase its effect
Cyclosporin reduces its metabolism while Methipred reduces the metabolism of Cyclosporin
May impact the effect of blood thinners

Systemic fungal infections and known hypersensitivity to components

Mild side effects with short courses
Potential serious side effects with long term, high doses
Range from fluid retention and weight gain to growth retardation in children and psychological disturbances

Adrenocortical insufficiency may persist after discontinuation
Enhanced effect on patients with hypothyroidism and in those with cirrhosis
Use cautiously in patients with ocular herpes simplex and hypoprothrombinemia
Careful observation of growth and development of infants and children on prolonged therapy

Rare reports of acute toxicity and/or death, supportive and symptomatic treatment