Pretonix 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 3.50 (50's pack: ৳ 175.00)

Medicine Details

Category Details
Generic Pantoprazole sodium
Company Pharmadesh laboratories ltd
Also available as
Pretonix 40 mg tablet

Indications

  • Peptic ulcer diseases
  • Gastroesophageal reflux diseases
  • Ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs)
  • Eradication of Helicobacter pylori (in combination with antibiotics)
  • Zollinger-Ellison Syndrome

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid production
  • Binds to H+/K+ATPase enzyme system
  • Inhibits basal and stimulated gastric acid secretion
  • Effect persists longer than 24 hours

Dosage & Administration

  • Oral administration
  • 40 mg daily for benign gastric ulcer
  • 20-40 mg daily for GERD
  • 40 mg daily for duodenal ulcer
  • 40 mg twice daily with antibiotics for duodenal ulcer associated with Helicobacter pylori
  • 20 mg daily for NSAID-associated gastric or duodenal ulcer
  • Initially 80 mg once daily for Zollinger-Ellison Syndrome
  • IV injection for duodenal ulcer, gastric ulcer, GERD, prevention of rebleeding in peptic ulcer, prophylaxis of acid aspiration, long-term management of Zollinger-Ellison Syndrome

Interaction

  • No significant drug interactions observed in clinical studies

Contraindications

  • Known hypersensitivity to any components of the formulation

Side Effects

  • Well tolerated in short-term and long-term treatment
  • Common side effects: headache, diarrhea
  • Rare side effects: abdominal pain, flatulence, rash, insomnia, hyperglycemia

Pregnancy & Lactation

  • US FDA Pregnancy Category B
  • No adequate and well-controlled studies in pregnant women
  • Excreted in human milk, use during pregnancy only if clearly needed
  • Decision should be made whether to discontinue nursing or discontinue the drug, considering benefit to the mother

Precautions & Warnings

  • Tablet should not be split, chewed, or crushed
  • Long-term therapy may lead to malabsorption of cyanocobalamin (Vitamin B12)
  • Increased risk of osteoporosis related disorders

Overdose Effects

  • No known symptoms of overdosage in humans
  • Highly protein bound, not readily dialyzable
  • Symptomatic and supportive management recommended

Therapeutic Class

  • Proton Pump Inhibitor

Reconstitution

  • IV injection for intravenous administration only
  • Reconstitution and administration guidelines provided for different dosages

Storage Conditions

  • Keep in a dry place, away from light and heat
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C16H15F2N3O4S
  • Chemical Structure Image provided

Common Questions about Pretonix 20 mg Tablet

  • Information about the tablet
  • Improvement timeline
  • Frequency of use
  • Instructions for storage and disposal
  • Effects on older adults
  • Time for medication to work
  • Safety in pregnancy and breastfeeding
  • Potential side effects
  • Missed dose instructions

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