Amotrex 500 mg/100 ml (IV Infusion)

100 ml bottle: ৳ 85.26

Medicine Details

Category Details
Generic Metronidazole
Company Aci limited
Also available as
Amotrex 200 mg tablet Amotrex 400 mg tablet Amotrex 200 mg suspension Amotrex ds 800 mg tablet

Title

Amotrex 500 mg/100 ml Injection

Categories

  • Medicine
  • Pharmaceutical

Description

Amotrex is an antibiotic medication used for the treatment and prevention of various infections caused by bacteria and parasites. It is available in tablet, suspension, gel, suppository, and intravenous infusion forms. The medicine is also effective in the prevention of post-operative infections, treatment of septicaemia, and other specified conditions.

DosageForms

  • Tablet
  • Suspension
  • Vaginal Gel
  • Suppository
  • IV Infusion

DosageGuidelines

  • Adults:
    • Trichomoniasis:
      • 200 mg tid or 400 mg bid for 7 days
      • 800 mg in the morning and 1-2 gm at night for 2 days
    • Intestinal Amoebiasis: 800 mg tid for 5 days
    • Extra-Intestinal & Asymptomatic Amoebiasis: 400-800 mg tid for 5-10 days
    • Giardiasis: 2 gm once daily for 3 days
    • Acute Ulcerative Gingivitis: 200 mg tid for 3 days
    • Acute Dental Infections: 200 mg tid for 3-7 days
    • Bacterial Vaginosis:
      • 400 mg bid for 7 days
      • 2 gm as a single dose for 1 days
    • Leg Ulcers and Pressure Sores: 400 mg tid for 7 days
    • Anaerobic Infections: 800 mg initially and then 400 mg tid for 7 days
    • Surgical Prophylaxis: 400 mg tid started 24 hours before surgery for 1 days
  • Children:
    • Trichomoniasis: Dose varies based on age
    • Intestinal Amoebiasis: Dose varies based on age
    • Extra-Intestinal & Asymptomatic Amoebiasis: Dose varies based on age
    • Giardiasis: Dose varies based on age
    • Acute Ulcerative Gingivitis: Dose varies based on age
    • Acute Dental Infections: Dose varies based on age
    • Bacterial Vaginosis: Dose varies based on age
    • Leg Ulcers and Pressure Sores: Dose varies based on age
    • Anaerobic Infections: Children 1-10 yrs: 7.5 mg/kg tid
    • Surgical Prophylaxis: Children 1-10 yrs: 7.5 mg/kg tid

Indications

  • Prevention of post-operative infections
  • Treatment of septicaemia
  • Urogenital trichomoniasis
  • Bacterial vaginosis
  • Amoebiasis
  • Giardiasis
  • Acute ulcerative gingivitis
  • Anaerobically infected leg ulcers
  • Acute dental infections
  • Antibiotic-associated pseudomembranous colitis

Pharmacology

Metronidazole, the active ingredient, is a member of the imidazole class of antibacterial drugs and is therapeutically classified as an antiprotozoal agent. Its 5-nitro group is reduced by anaerobes metabolically, leading to bactericidal action through interaction with DNA.

Interaction

  • Disulfiram
  • Alcohol
  • Oral anticoagulant therapy
  • Lithium
  • Cyclosporin
  • Phenytoin or phenobarbital
  • 5-Fluorouracil
  • Busulfan

Contraindications

Hypersensitivity to Metronidazole or other Nitroimidazole derivatives

SideEffects

  • Metallic taste
  • Nausea
  • Vomiting
  • Diarrhoea
  • Drowsiness
  • Rashes

PregnancyAndLactation

Category B. Limited studies in pregnant women, caution in use during pregnancy. Excreted in human milk, caution in use during lactation.

PrecautionsAndWarnings

  • Regular hematological tests (especially leucocyte count)
  • Monitoring for adverse reactions (e.g., neuropathy)
  • Caution in hepatic encephalopathy patients

UseInSpecialPopulations

  • HepaticImpairment: Reduced dosage recommended for patients with advanced hepatic insufficiency
  • RenalImpairment: No need for dosage reduction, efficient removal during haemodialysis

OverdoseEffects

Reported overdose symptoms include vomiting, ataxia, and slight disorientation. Supportive treatment recommended for suspected massive overdoses.

TherapeuticClass

  • Amoebicides
  • Antidiarrhoeal
  • Antiprotozoal

StorageConditions

Store below 30°C, protect from light, and keep out of the reach of children. Do not use after the expiry date.

CommonQuestions

  • Uses of Amotrex 500 mg/100 ml IV Infusion
  • Side effects of Amotrex 500 mg/100 ml IV Infusion
  • Contraindications to Amotrex 500 mg/100 ml IV Infusion
  • Safety during pregnancy
  • Effect of higher than recommended dose

QuickTips

  • Treats infections caused by bacteria and parasites
  • May cause side effects like nausea and metallic taste
  • Do not drink alcohol during treatment
  • Inform doctor if liver disease is present

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