Protonil 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)

Strip Price: ৳ 60.00

Medicine Details

Category	Details
Generic	Pantoprazole sodium
Company	Renata limited
Also available as	Protonil 40 mg tablet

Indications

Peptic ulcer diseases
Gastroesophageal reflux diseases
Ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs)
Eradication of Helicobacter pylori
Zollinger-Ellison Syndrome

Pharmacology

Protonil is a proton pump inhibitor that suppresses the final step in gastric acid production by covalently binding to the H+/K+ATPase enzyme system at the surface of the gastric parietal cell.

Dosage & Administration

Benign gastric ulcer: 40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed
Gastro-esophageal reflux disease: 20-40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed; maintenance dose is 20 mg daily, which may be increased to 40 mg daily
Duodenal ulcer: 40 mg daily in the morning for 2 weeks, continued for further 2 weeks if not fully healed
Duodenal ulcer associated with Helicobacter pylori: Pantoprazole is recommended at a dose of 40 mg twice daily in association with antimicrobial agents for one week
Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily for long-term treatment
Zollinger-Ellison Syndrome: Initially 80 mg once daily adjusted according to response; daily doses above 80 mg given in 2 divided doses
IV Injection: Dosage varies for different conditions

Interaction

No significant drug interactions have been observed in clinical studies.

Contraindications

Pantoprazole is contraindicated in patients with known hypersensitivity to any of the components of the formulation.

Side Effects

Headache
Diarrhea
Abdomial pain
Flatulence
Rash
Insomnia
Hyperglycemia

Pregnancy & Lactation

US FDA Pregnancy Category of Pantoprazole is B. It should be used during pregnancy only if clearly needed. Pantoprazole has been shown to be excreted in human milk.

Precautions & Warnings

Tablet should not be split, chewed or crushed
Long-term therapy may lead to malabsorption of cyanocobalamin (Vitamin B12)
May increase the risk of osteoporosis related disorders

Overdose Effects

There are no known symptoms of overdosage in humans. Protonil is highly protein bound and not readily dialyzable.

Therapeutic Class

Proton Pump Inhibitor

Reconstitution

Protonil IV injection should be given as a slow intravenous injection
The solution for IV injection is obtained by adding 10 ml 0.9% Sodium Chloride Injection to the vial containing powder
Protonil IV infusion should be given as an intravenous infusion over a period of approximately 15 minutes
The reconstituted solution may be stored at room temperature for a maximum 4 hours

Storage Conditions

Keep in a dry place, away from light and heat. Keep out of the reach of children.

Chemical Structure

Molecular Formula: C16H15F2N3O4S

Common Questions about Protonil 20 mg Tablet

Protonil 20 mg Tablet is a proton pump inhibitor used to treat various conditions
Duration and frequency of usage should follow doctor's instructions
Should be taken prior to the meal, approximately 30 minutes before it
Storage and disposal instructions should be followed
May increase the risk for bone fractures, especially with longer use, higher doses in older adults
Start to feel better within 2 to 3 days; may take up to 4 weeks for proper effects