Metrogard 400 mg (Tablet)

Unit Price: ৳ 1.26

Medicine Details

Category	Details
Generic	Metronidazole
Company	Guardian healthcare ltd

Title

Metrogard 400 mg Tablet

Description

Metrogard 400 mg Tablet is an antibiotic medication that prevents the growth of bacteria and parasites. It is used for the treatment and prevention of viral, bacterial, and parasitic infections.

Color Options

White
Off-White

Dosage Form

Tablet

Dosage Instructions

200 mg tid or 400 mg bid for 7 days (Adults & Children over 10 yrs)
800 mg in the morning and 1-2 gm at night for 2 days (Adults & Children over 10 yrs)
2 gm as a single dose for 1 days (Adults & Children over 10 yrs)
100 mg tid for Children 7-10 yrs
100 mg bid for Children 3-7 yrs
50 mg tid for Children 1-3 yrs
800 mg tid for 5 days (Adults & Children over 10 yrs)
400 mg tid for Children 7-10 yrs
200 mg qid for Children 3-7 yrs
200 mg tid for Children 1-3 yrs
400-800 mg tid for 5-10 days (Adults & Children over 10 yrs)
200-400 mg tid for Children 7-10 yrs
100-200 mg qid for Children 3-7 yrs
100-200 mg tid for Children 1-3 yrs
2 gm once daily for 3 days (Adults & Children over 10 yrs)
1 gm once daily for Children 7-10 yrs
600-800 mg once daily for Children 3-7 yrs
500 mg once daily for Children 1-3 yrs
Other specific dosage instructions for various conditions and age groups

Mode of Action

Metronidazole, the active ingredient, is an imidazole class antibacterial drug that is classified therapeutically as an antiprotozoal agent. It interacts with DNA and exhibits bactericidal actions.

Indications

Prevention of post-operative infections due to anaerobic bacteria
Treatment of septicaemia, bacteraemia, peritonitis, brain abscess, pelvic abscess, pelvic cellulitis, post-operative wound infections caused by anaerobes
Urogenital trichomoniasis
Bacterial vaginosis
Amoebiasis (intestinal, extra-intestinal, and in symptomless cyst passers)
Giardiasis
Acute ulcerative gingivitis
Anaerobically infected leg ulcers and pressure sores
Acute dental infections due to anaerobic organisms
Antibiotic-associated pseudomembranous colitis

Interaction

Disulfiram: Psychotic reactions reported when used concurrently
Alcohol: Consumption during therapy and for at least one day afterwards should be avoided
Oral anticoagulant therapy (warfarin type): Potentiation of the anticoagulant effect, increased hemorrhagic risk
Lithium: Metronidazole may increase plasma levels of lithium
Cyclosporin: Close monitoring of serum levels and serum creatinine is necessary
Phenytoin or phenobarbital: Increased elimination of Metronidazole resulting in reduced plasma levels
5-Fluorouracil: Reduced clearance leading to increased toxicity
Busulfan: Metronidazole may increase plasma levels of busulfan, leading to severe toxicity

Contraindications

Metronidazole is contraindicated in patients with a history of hypersensitivity to Metronidazole or other Nitroimidazole derivatives.

Side Effects

Metallic taste
Nausea
Vomiting
Diarrhoea
Drowsiness
Rashes

Pregnancy & Lactation

US FDA Pregnancy Category of Metronidazole is B. Caution is advised during pregnancy and nursing.

Precautions & Warnings

Regular hematological tests recommended if administered longer than usual duration
Caution advised for patients with hepatic encephalopathy
Patients should be warned that Metrogard may darken urine

Special Populations

Hepatic Impairment: Dosage adjustment and caution advised for patients with advanced hepatic insufficiency
Renal Impairment: No routine adjustment in the dosage needed for patients with renal failure undergoing intermittent peritoneal dialysis (IDP) or continuous ambulatory peritoneal dialysis (CAPD)

Overdose Effects

Symptomatic and supportive treatment should be instituted in case of suspected massive overdoses. No specific antidote available.

Therapeutic Class

Amoebicides, Anti-diarrhoeal, Antiprotozoal

Storage Conditions

Store below 30°C. Keep protected from light and out of the reach of children. Do not use later than the date of expiry.