Proton-P 40 mg (Tablet (Enteric Coated))

Unit Price: ৳ 7.00 (6 x 10: ৳ 420.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Pantoprazole sodium
Company Aristopharma ltd
Also available as
Proton p 20 mg tablet Proton p 40 mg injection

Indications

  • Peptic ulcer diseases
  • Gastroesophageal reflux diseases
  • Ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs)
  • Eradication of Helicobacter pylori (in combination with antibiotics)
  • Zollinger-Ellison Syndrome

Pharmacology

Proton-P is a proton pump inhibitor that suppresses the final step in gastric acid production by covalently binding to the H+/K+ATPase enzyme system at the surface of the gastric parietal cell. It leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus that persists longer than 24 hours.

Dosage & Administration

  • 40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed for benign gastric ulcer
  • 20-40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed for gastro-esophageal reflux disease
  • 40 mg daily in the morning for 2 weeks, continued for further 2 weeks if not fully healed for duodenal ulcer
  • 40 mg twice daily in association with antimicrobial agents for duodenal ulcer associated with Helicobacter pylori
  • 20 mg daily for those require long-term NSAID treatment for prophylaxis of NSAID-associated gastric or duodenal ulcer
  • Initially 80 mg once daily adjusted according to response for Zollinger-Ellison Syndrome
  • 40 mg once daily for 7-10 days for duodenal ulcer and gastric ulcer IV injection
  • 40 mg once daily for 7-10 days for gastroesophageal reflux disease associated with a history of erosive esophagitis IV injection
  • IV 80 mg, followed by 8 mg/hour infusion for 72 hours for prevention of rebleeding in peptic ulcer
  • 80 mg IV every 12 h for 24 h for prophylaxis of acid aspiration
  • 80 mg IV every 12 hours for long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions

Interaction

No significant drug interactions have been observed in clinical studies

Contraindications

Pantoprazole is contraindicated in patients with known hypersensitivity to any of the components of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Abdominal pain
  • Flatulence
  • Rash
  • Insomnia
  • Hyperglycemia

Pregnancy & Lactation

FDA Pregnancy Category B. Should be used during pregnancy only if clearly needed. Excreted in human milk.

Precautions & Warnings

Proton-P tablet should not be split, chewed or crushed. Long-term therapy of Proton-P may lead to malabsorption of cyanocobalamin (Vitamin B12) or may increase the risk of osteoporosis related disorders

Overdose Effects

No known symptoms of overdosage in humans. Highly protein bound and not readily dialyzable

Therapeutic Class

Proton Pump Inhibitor

Reconstitution

  • Proton-P IV injection should be given as a slow intravenous injection. The reconstituted solution may be stored at room temperature for a maximum of 4 hours. Proton-P IV infusion should be given as an intravenous infusion over a period of approximately 15 minutes and may be stored at room temperature for a maximum of 24 hours from the time of initial reconstitution

Storage Conditions

Keep in a dry place, away from light and heat. Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C16H15F2N3O4S
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-859-pantoprazole-sodium-chemical-structure-cnfmhAVGwpLzfJYlfu9P.svg

Common Questions about Proton-P 40 mg Tablet

  • Proton-P 40 mg Tablet is a proton pump inhibitor. It suppresses the final step in gastric acid production. It is used to treat Peptic ulcer diseases, GERD, Ulcer induced by NSAIDs, Eradication of Helicobacter pylori, Zollinger-Ellison Syndrome
  • Proton-P 40 mg Tablet is to be taken till the time you see an improvement in your health conditions
  • Proton-P 40 mg Tablet should be taken in the dosage as prescribed by the doctor
  • Proton-P 40 mg Tablet should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets
  • Proton-P 40 mg Tablet may increase the risk for bone fractures, especially with longer use, higher doses in older adults
  • You should start to feel better within 2 to 3 days. It may take up to 4 weeks for this medication to work properly so you may still have some symptoms during this time
  • Rare cases of weight gain are associated with the consumption of Proton-P 40 mg Tablet. Consult your doctor for any weight-related concern
  • The side effects of Proton-P 40 mg Tablet aren't that common. Still, people face the following issues sometimes - headache, diarrhea, constipation, and allergic reaction
  • It is advised not to take Proton-P 40 mg Tablet unless prescribed by your doctor during pregnancy or breastfeeding
  • If you miss a dose of Proton-P 40 mg Tablet, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and take your next dose at the regular time

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