Orbizol 200 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 25.00

Medicine Details

Category	Details
Generic	Metronidazole
Company	Orbit pharmaceuticals ltd
Also available as	Orbizol 400 mg tablet

Title

Orbizol 200 mg/5 ml Suspension

Description

Orbizol is indicated in the treatment and prevention of viral, parasitic, and bacterial infections such as trichomoniasis, septicaemia, bacteraemia, peritonitis, brain abscess, pelvic abscess, pelvic cellulitis, post-operative wound infections, urogenital trichomoniasis, bacterial vaginosis, amoebiasis, giardiasis, acute ulcerative gingivitis, anaerobically infected leg ulcers, pressure sores, acute dental infections, and antibiotic-associated pseudomembranous colitis.

DosageAndAdministration

TabletAndSuspension:
- Trichomoniasis:
  - 200 mg tid or 400 mg bid for 7 days
  - 800 mg in the morning and 1-2 gm at night for 2 days
  - 2 gm as a single dose for 1 day
- IntestinalAmoebiasis: 800 mg tid for 5 days
- ExtraIntestinalAndAsymptomaticAmoebiasis: 400-800 mg tid for 5-10 days
- Giardiasis: 2 gm once daily for 3 days
- AcuteUlcerativeGingivitis: 200 mg tid for 3 days
- BacterialVaginosis:
  - 400 mg bid for 7 days
  - 2 gm as a single dose for 1 day
- LegUlcersAndPressureSores: 400 mg tid for 7 days
- AnaerobicInfections: 800 mg initially and then 400 mg tid for 7 days
- SurgicalProphylaxis: 400 mg tid started 24 hours before surgery for 1 day
VaginalGel: One applicator full intravaginally once or twice a day for 5 days
Suppository:
- AnaerobicInfections:
  - Adults: 1 g every 8 hours for 3 days, then 1 g every 12 hours
  - Children: 5-10 years: 500 mg every 8 hours for 3 days, then every 12 hours; Over 10 years adult dose
- SurgicalProphylaxis:
  - Adults: 1 g 2 hours before surgery; up to 3 further doses of 1 g may be given every 8 hours for high-risk procedures
  - Children: 5-10 years: 500 mg 2 hours before surgery; up to 3 further doses of 500 mg may be given every 8 hours for high-risk procedures
IVInfusion:
- AdultsAndChildrenOver12Years: Infuse 500 mg 8 hourly at a rate of 5 ml/minute; maximum of 4 g should not be exceeded during a 24-hour period. Treatment for 7 days is sufficient for most patients, but treatment can be extended.

Interaction

Disulfiram: Psychotic reactions have been reported in patients using Orbizol and disulfiram concurrently.
Alcohol: Alcoholic beverages and drugs containing alcohol should not be consumed during therapy and for at least one day afterwards.
Lithium: Plasma levels of lithium may be increased by Orbizol.
Cyclosporin: Serum cyclosporin and serum creatinine should be closely monitored when co-administration is necessary.
Phenytoin or phenobarbital: increased elimination of Orbizol resulting in reduced plasma levels.
5-Fluorouracil: Reduced clearance of 5-fluorouracil resulting in increased toxicity.
Busulfan: Plasma levels of busulfan may be increased by Orbizol, which may lead to severe busulfan toxicity.

Contraindications

Metronidazole is contraindicated in patients with a history of hypersensitivity to Metronidazole or other Nitroimidazole derivatives.

SideEffects

Metallic taste
Nausea
Vomiting
Diarrhoea
Drowsiness
Rashes

PregnancyAndLactation

US FDA Pregnancy Category of Metronidazole is B. Caution should be exercised when administered to a nursing woman.

PrecautionsAndWarnings

Hematological tests, especially leucocyte count should be carried out regularly for longer durations of administration
Administered with caution to patients with hepatic encephalopathy
May darken urine

UseInSpecialPopulations

HepaticImpairment: Administered with caution and dosage should be reduced in patients with hepatic encephalopathy
RenalImpairment: No routine adjustment in the dosage, efficiently removed during haemodialysis

OverdoseEffects

Single oral doses of Orbizol, up to 12 g have been reported in suicide attempts and accidental overdoses. Symptoms were limited to vomiting, ataxia, and slight disorientation.

TherapeuticClass

Amoebicides, Anti-diarrhoeal, Antiprotozoal

StorageConditions

Store below 30°C, protected from light, out of the reach of children, and not beyond the expiration date

CommonlyAskedQuestions

WhatIsOrbizolSuspension: An antibiotic medication for preventing the growth of bacteria and parasites
UsesOfOrbizolSuspension: Treatment and prevention from viral, parasitic and bacterial infections
SideEffectsOfOrbizolSuspension: Side effects such as diarrhoea, headache, weakness, painful urination, trouble sleeping, numbness, muscle weakness, and mouth ulcers