Amirid 400 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metronidazole |
| Company | Veritas pharmaceuticals ltd |
Title
Amirid 400 mg Tablet
Categories
- Medicine
- Antibiotic
- Antiprotozoal
- Amoebicide
Description
Amirid 400 mg Tablet is an antibiotic medication that prevents the growth of bacteria and parasites. It is indicated for the prevention of post-operative infections, treatment of various infections caused by anaerobes, urogenital trichomoniasis, bacterial vaginosis, amoebiasis, giardiasis, acute ulcerative gingivitis, anaerobically infected leg ulcers, pressure sores, acute dental infections, and antibiotic-associated pseudomembranous colitis.
DosageAndAdministration
- Recommended dosage varies based on the condition being treated, age, and route of administration
- Dosage forms include tablets, suspension, vaginal gel, suppository, and IV infusion
Pharmacology
Metronidazole is a member of the imidazole class of antibacterial drug and is classified therapeutically as an antiprotozoal agent. The 5-nitro group of Metronidazole is reduced by anaerobes metabolically, and the reduced form interacts with DNA, giving bactericidal action.
Interaction
- Disulfiram
- Alcohol
- Warfarin
- Lithium
- Cyclosporin
- Phenytoin
- Phenobarbital
- 5-Fluorouracil
- Busulfan
Contraindications
- Hypersensitivity to Metronidazole or other Nitroimidazole derivatives
SideEffects
- Metallic taste
- Nausea
- Vomiting
- Diarrhea
- Drowsiness
- Rashes
PregnancyAndLactation
- FDA Pregnancy Category B
- Use during pregnancy only if clearly needed
- Excreted in human milk, caution during nursing
PrecautionsAndWarnings
- Regular hematological tests recommended if administered longer than usual duration
- Caution in hepatic encephalopathy patients
- May darken urine
SpecialPopulations
- HepaticImpairment: Substantial impairment of clearance may occur
- RenalImpairment: No need for dosage reduction, efficient removal during hemodialysis
StorageConditions
Store below 30°C, protected from light, and out of reach of children
CommonlyAskedQuestions
- What are the uses of Amirid 400 mg Tablet?
- What are the side effects of Amirid 400 mg Tablet?
- How long do I need to use Amirid 400 mg Tablet before I see an improvement?
- What are the contraindications to Amirid 400 mg Tablet?
- Is Amirid 400 mg Tablet safe to use when pregnant?
- Will Amirid 400 mg Tablet be more effective if taken in more than the recommended dose?
OverdoseEffects
Symptoms were limited to vomiting, ataxia, and slight disorientation. No specific antidote for Amirid overdosages.
TherapeuticClass
Amoebicides, Anti-diarrheal, Antiprotozoal
InteractionDetails
- Disulfiram: Psychotic reactions reported when used concurrently with Amirid
- Alcohol: Should not be consumed during therapy and for at least one day afterwards
- Warfarin: Potentiation of anticoagulant effect
- Lithium: Plasma levels may be increased by Amirid
- Cyclosporin: Serum levels and creatinine should be closely monitored during co-administration
- Phenytoin: Increased elimination of Amirid resulting in reduced plasma levels
- 5-fluorouracil: Reduced clearance resulting in increased toxicity
- Busulfan: Plasma levels may be increased by Amirid, leading to severe toxicity
Precautions
- CompellingReasons: Regular hematological tests recommended if administered longer than usual duration
- HepaticEncephalopathy: Administered with caution
- DarkeningUrine: Patients should be warned that Amirid may darken urine