Micoderm 2% w/w (Cream)
10 gm tube: ৳ 40.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Miconazole nitrate |
| Company | Drug international ltd |
| Also available as |
Title
- Micoderm Oral Gel
Categories
- Oral Care
- Antifungal Medication
Description
- Micoderm oral gel is indicated for the treatment of oral and gastrointestinal candidiasis, eradication of fungal colonization, treatment of super infections due to gram-positive bacteria, and various dermatomycoses such as Tinea pedis, Tinea corporis, Tinea manuum, and Candidial infections.
Color Options
- Clear gel
Function
- Antifungal treatment
- Bacterial infection treatment
Dosage Form
- Oral gel
- Cream
Age Group
- Infants 4-24 months
- Adults
- Children 2 years and older
Dosage Instructions
- Apply 4 times a day after meals for oral candidosis
- Cover affected areas twice daily for tinea pedis, tinea cruris, tinea corporis, and cutaneous candidiasis
- Apply once daily for tinea versicolor
Administration Method
- Apply directly to affected area with a clean finger
- Remove dental prosthesis at night and brush with the gel for oral candidosis
Pharmacodynamics
- Antifungal activity against common dermatophytes and yeasts
- Antibacterial activity against certain gram-positive bacilli and cocci
- Inhibition of demethylation step in ergosterol biosynthesis
- Disruption of fungal cell membrane leading to cell death
Pharmacokinetics
- Low oral bioavailability (25-30%)
- Systemic absorption after oral gel administration
- Plasma protein binding (88.2%)
- Metabolism of absorbed Miconazole
- Excretion in urine (<1%)
- Terminal plasma half-life (20-25 hours)
- Similar elimination half-life in renal-impaired patients
Interaction
- Avoid concomitant treatment with Terfenadine, Astemizole, and Cisapride
- May delay Phenytoin and Cyclosporine metabolism
- Monitor anticoagulant effect and phenytoin plasma level when used concomitantly
Contraindications
- Known hypersensitivity to the active ingredient
Side Effects
- Nausea
- Vomiting
- Diarrhea with long-term use
- Rare allergic reactions
Pregnancy & Lactation
- Avoid in pregnant women if possible
- Caution with nursing women due to potential excretion in human milk
Precautions & Warnings
- Monitor anticoagulant effect if used concomitantly
- Avoid obstruction of the throat in infants and young children
Overdose Effects
- Vomiting
- Diarrhea
- Symptomatic and supportive treatment
Therapeutic Class
- Aural Anti-fungal preparations
Storage Conditions
- Dry place away from light and heat
- Keep out of reach of children