G-Miconazole 2% w/w (Cream)
Medicine Details
| Category | Details |
|---|---|
| Generic | Miconazole nitrate |
| Company | Gonoshasthaya pharma ltd |
Title
G-G-Miconazole Oral Gel
Categories
- Pharmaceuticals
- Medical Supplies
Description
G-G-Miconazole oral gel is indicated for the treatment of oral and gastrointestinal candidiasis, eradication of fungal colonization, treatment of infections due to gram-positive bacteria, and dermatomycoses such as tinea pedis, tinea corporis, tinea manuum, and tinea cruris. It possesses antifungal and antibacterial activities. The oral bioavailability is low, and it is primarily metabolized, with a terminal plasma half-life of 20-25 hours. The dosage varies for oropharyngeal and gastrointestinal candidosis, and early relief of symptoms is experienced within 2 to 3 days. Contraindicated in patients with known hypersensitivity to the active ingredient. Possible side effects include nausea, vomiting, diarrhea, and allergic reactions. No information is available regarding the safety of Miconazole oral gel during pregnancy, and caution is advised during lactation. Precautions are necessary when used concomitantly with anticoagulants and phenytoin. Accidental overdosage may cause vomiting and diarrhea. It belongs to the therapeutic class of aural anti-fungal preparations and should be stored in a dry place away from light and heat, out of the reach of children.
Attributes
- Indications:
- Treatment of oral and gastrointestinal candidiasis
- Eradication of fungal colonization in the mouth and gastrointestinal tract
- Treatment of super infections due to gram-positive bacteria
- Treatment of dermatomycoses such as tinea pedis, tinea corporis, tinea manuum, and tinea cruris
- Treatment of candidial infections, intertrigo, perianal infections, stomatitis angularis, balanoposthitis, otitis externa, and infections of the skin
- Pharmacology:
- Possesses antifungal activity against common dermatophytes and yeasts
- Has antibacterial activity against certain gram-positive bacilli and cocci
- Inhibition of a demethylation step in ergosterol biosynthesis
- Low oral bioavailability (25-30%)
- Bound to plasma proteins primarily to serum albumin and red blood cells
- Metabolized with less than 1% excreted unchanged in urine
- Terminal plasma half-life of 20-25 hours
- Similar elimination half-life in any renal impaired patient
- Dosage:
- Infants 4-24 months: 1.25 ml (1/4 measuring spoon) 4 times a day after meals
- Adults and children 2 years and older: 2.5 ml (1/2 measuring spoon) 4 times a day after meals
- Gastrointestinal tract candidosis dosage for infants and children with difficulty swallowing tablets
- Apply missed dose as soon as remembered, omit if next dosing time is near
- Miconazole cream application frequency and duration for different conditions
- Administration:
- Application frequency and method for localized lesions of the mouth
- Interaction:
- Avoid concomitant treatment with Terfenadine, Astemizole, and Cisapride
- May delay Phenytoin and Cyclosporine metabolism
- Contraindications:
- Known hypersensitivity to the active ingredient
- Side Effects:
- Occasional nausea and vomiting
- Diarrhea with long-term use
- Rare allergic reactions
- Pregnancy & Lactation:
- No information available regarding safety during pregnancy
- Caution advised when administered to nursing women
- Precautions & Warnings:
- Monitor anti-coagulant effect when used concomitantly
- Monitor phenytoin plasma level in concomitant use
- Caution in infants and young children to prevent throat obstruction
- Overdose Effects:
- Accidental overdosage may cause vomiting and diarrhea
- Treatment is symptomatic and supportive
- Therapeutic Class:
- Aural Anti-fungal preparations
- Storage Conditions:
- Keep in a dry place away from light and heat
- Keep out of the reach of children