Anquil 15 mg/3 ml (IM/IV Injection)

3 ml ampoule: ৳ 120.00 (1 x 5: ৳ 600.00)

Medicine Details

Category Details
Generic Midazolam
Company General pharmaceuticals ltd
Also available as
Anquil 75 mg tablet Anquil 15 mg tablet

Indications

  • Short-term treatment of insomnia
  • Sedation in premedication before surgical or diagnostic procedures

Description

  • Sleep-inducing agent
  • Rapid onset and short duration of action
  • Anxiolytic effect
  • Anticonvulsant effect
  • Muscle-relaxant effect

Pharmacology

  • Mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
  • Increase the activity of GABA
  • Produce a sedating effect
  • Relax skeletal muscles
  • Induce sleep, anesthesia, and amnesia
  • Bind to the benzodiazepine site on GABA-A receptors
  • Potentiate the effects of GABA by increasing the frequency of chloride channel opening

Dosage & Administration

  • Oral dosage for adults: 7.5-15 mg daily
  • Oral dosage in elderly and debilitated patients: 7.5 mg
  • Premedication dosage: 15 mg 30-60 minutes before the procedure
  • Intravenous dosage for endoscopic or cardiovascular procedures in healthy adults: approximately 2.5 mg
  • Intravenous dosage for induction of anesthesia: 10-15 mg
  • Intramuscular dosage for adults: 0.07-0.1 mg/kg body weight
  • Intramuscular dosage for children: 0.15-0.20 mg/kg
  • Intramuscular dosage for elderly and debilitated patients: 0.025-0.05 mg/kg
  • Rectal administration dosage in children for preoperative sedation: 0.35-0.45 mg/kg 20-30 min before induction of general anesthesia

Interaction

  • Enhance the central sedative effect of neuroleptics
  • Enhance the central sedative effect of tranquillizers
  • Enhance the central sedative effect of antidepressants
  • Enhance the central sedative effect of sleep-inducing drugs
  • Enhance the central sedative effect of analgesics
  • Enhance the central sedative effect of anaesthetics
  • Enhance the central sedative effect of antipsychotics
  • Enhance the central sedative effect of anxiolytics
  • Enhance the central sedative effect of antiepileptic drugs
  • Enhance the central sedative effect of sedative antihistamines

Contraindications

  • Severe respiratory insufficiency
  • Severe hepatic insufficiency
  • Myasthenia gravis
  • Sleep apnea syndrome
  • Known hypersensitivity to benzodiazepines or any component of the product

Side Effects

  • Drowsiness during daytime
  • Confusion
  • Fatigue
  • Headache
  • Muscle weakness
  • Respiratory depression following parenteral administration
  • Apnea following parenteral administration
  • Variations in blood pressure following parenteral administration
  • Fluctuations in pulse rate following parenteral administration

Pregnancy & Lactation

  • Avoid during pregnancy unless no safer alternative
  • Do not administer to breastfeeding mothers

Precautions & Warnings

  • Administer IV very slowly

Overdose Effects

  • Coma
  • Areflexia
  • Cardiorespiratory depression
  • Apnea
  • Controlled with benzodiazepine antagonist flumazenil

Therapeutic Class

  • Benzodiazepine hypnotics
  • Benzodiazepine sedatives

Storage Conditions

  • Protect from light and moisture
  • Store in a cool and dry place
  • Keep out of the reach of children

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