Hypnofast 15 mg/3 ml (IM/IV Injection)

3 ml ampoule: ৳ 150.00

Medicine Details

Category Details
Generic Midazolam
Company Incepta pharmaceuticals ltd
Also available as
Hypnofast 75 mg tablet Hypnofast 5 mg injection Hypnofast 5 mg injection

Indications

  • Short-term treatment of insomnia
  • Sedation in premedication before surgical or diagnostic procedures

Description

Sleep-inducing agent with rapid onset and short duration of action. Also exerts an anxiolytic, anticonvulsant, and muscle-relaxant effect.

Pharmacology

Actions mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Increases GABA activity, producing sedating effect, relaxing skeletal muscles, and inducing sleep, anesthesia, and amnesia.

Dosage & Administration

  • Oral dosage for adults: 7.5-15 mg daily
  • Oral dosage in elderly and debilitated patients: 7.5 mg
  • Oral dosage in premedication: 15 mg given 30-60 minutes before the procedure
  • Intravenous administration for endoscopic or cardiovascular procedures in healthy adults: Approximately 2.5 mg
  • Intravenous administration for induction of anesthesia: 10-15 mg
  • Intramuscular administration for adults: 0.07-0.1 mg/kg body weight. The usual dose is about 5 mg
  • Intramuscular administration for children: 0.15-0.20 mg/kg
  • Intramuscular administration for elderly and debilitated patients: 0.025-0.05 mg/kg
  • Rectal administration in children for preoperative sedation: Rectal administration of the ampoule solution (0.35-0.45 mg/kg) 20-30 min before induction of general anesthesia

Interaction

Can enhance the central sedative effect of various drugs including neuroleptics, tranquillizers, antidepressants, analgesics, anesthetics, and antipsychotics

Contraindications

Must not be given to patients with severe respiratory insufficiency, severe hepatic insufficiency, myasthenia gravis, sleep apnea syndrome, and known hypersensitivity to benzodiazepines

Side Effects

  • Drowsiness
  • Confusion
  • Fatigue
  • Headache
  • Muscle weakness
  • Respiratory depression
  • Apnea
  • Variations in blood pressure and pulse rate

Pregnancy & Lactation

Should be avoided during pregnancy unless no safer alternative. Passes into breast milk, so should not be administered to breast-feeding mothers

Precautions & Warnings

IV administration should be very slow

Overdose Effects

May lead to coma, areflexia, cardiorespiratory depression, and apnea. Controlled with benzodiazepine antagonist flumazenil

Therapeutic Class

  • Benzodiazepine hypnotics
  • Benzodiazepine sedatives

Storage Conditions

Protect from light and moisture. Store in a cool and dry place. Keep out of the reach of children.

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