Hypnofast 5 mg/ml (IM/IV Injection)

1 ml ampoule: ৳ 50.00

Medicine Details

Category Details
Generic Midazolam
Company Incepta pharmaceuticals ltd
Also available as
Hypnofast 75 mg tablet Hypnofast 15 mg injection Hypnofast 5 mg injection

Indications

  • Short-term treatment of insomnia
  • Sedation in premedication before surgical or diagnostic procedures

Description

  • Sleep-inducing agent
  • Rapid onset and short duration of action
  • Anxiolytic effect
  • Anticonvulsant effect
  • Muscle-relaxant effect

Pharmacology

  • Mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
  • Increase the activity of GABA
  • Produces a sedating effect
  • Relaxes skeletal muscles
  • Induces sleep, anesthesia, and amnesia
  • Binds to the benzodiazepine site on GABA-A receptors
  • Potentiates the effects of GABA by increasing the frequency of chloride channel opening

Dosage & Administration

  • Oral dosage for adults: 7.5-15 mg daily
  • Oral dosage for elderly and debilitated patients: 7.5 mg
  • Oral dosage for premedication: 15 mg given 30-60 minutes before the procedure
  • Intravenous administration for endoscopic or cardiovascular procedures: Initial dose approximately 2.5 mg in healthy adults
  • Intravenous administration for induction of anesthesia: 10-15 mg
  • Intramuscular administration for adults: 0.07-0.1 mg/kg body weight
  • Intramuscular administration for children: 0.15-0.20 mg/kg
  • Intramuscular administration for elderly and debilitated patients: 0.025-0.05 mg/kg
  • Rectal administration in children for preoperative sedation: 0.35-0.45 mg/kg 20-30 min before induction of general anesthesia

Interaction

  • Enhances the central sedative effect of various drugs including neuroleptics, tranquillizers, antidepressants, analgesics, anesthetics, antipsychotics, anxiolytics, antiepileptic drugs, and sedative antihistamines

Contraindications

  • Severe respiratory insufficiency
  • Severe hepatic insufficiency
  • Myasthenia gravis
  • Sleep apnea syndrome
  • Known hypersensitivity to benzodiazepines or any component of the product

Side Effects

  • Drowsiness during daytime
  • Confusion
  • Fatigue
  • Headache
  • Muscle weakness
  • Respiratory depression
  • Apnea
  • Variations in blood pressure
  • Pulse rate fluctuations

Pregnancy & Lactation

  • Avoid during pregnancy unless no safer alternative
  • Passes into breast milk, should not be administered to breastfeeding mothers

Precautions & Warnings

  • IV administration should be very slow

Overdose Effects

  • Coma
  • Areflexia
  • Cardiorespiratory depression
  • Apnea
  • Controlled with benzodiazepine antagonist flumazenil

Therapeutic Class

  • Benzodiazepine hypnotics
  • Benzodiazepine sedatives

Storage Conditions

  • Protect from light and moisture
  • Store in a cool and dry place
  • Keep out of the reach of children

Related Brands