Midzo 7.5 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Midazolam |
| Company | Renata limited |
| Also available as |
Indications
- Short-term treatment of insomnia
- Sedation in premedication before surgical or diagnostic procedures
Description
A sleep-inducing agent characterized by a rapid onset and short duration of action. It also exerts an anxiolytic, anticonvulsant and muscle-relaxant effect.
Pharmacology
The actions of benzodiazepines such as midazolam are mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
Dosage & Administration
- Oral dosage for adults: 7.5-15 mg daily
- Oral dosage for elderly and debilitated patients: 7.5 mg
- Intravenous administration for endoscopic or cardiovascular procedures in healthy adults: Approximately 2.5 mg
- Intravenous administration for induction of anesthesia: 10-15 mg
- Intramuscular administration for adults: 0.07-0.1 mg/kg body weight
- Intramuscular administration for children: 0.15-0.20 mg/kg
- Intramuscular administration for elderly and debilitated patients: 0.025-0.05 mg/kg
- Rectal administration in children for preoperative sedation: Rectal administration of the ampoule solution (0.35-0.45 mg/kg) 20-30 min before induction of general anesthesia
Interaction
Midzo can enhance the central sedative effect of various drugs such as neuroleptics, tranquillizers, antidepressants, and sedative antihistamines.
Contraindications
- Severe respiratory insufficiency
- Severe hepatic insufficiency
- Myasthenia gravis
- Sleep apnea syndrome
- Known hypersensitivity to benzodiazepines
Side Effects
- Drowsiness during daytime
- Confusion
- Fatigue
- Headache
- Muscle weakness
- Respiratory depression
- Apnea
- Variations in blood pressure and pulse rate
Pregnancy & Lactation
- Midazolam should be avoided during pregnancy unless there is no safer alternative
- It should not be administered to breastfeeding mothers.
Precautions & Warnings
Midzo IV should be administered very slowly.
Overdose Effects
Extreme overdosage may lead to coma, areflexia, cardiorespiratory depression, and apnea. The effects of overdosage can be controlled with benzodiazepine antagonist flumazenil.
Therapeutic Class
- Benzodiazepine hypnotics
- Benzodiazepine sedatives
Storage Conditions
Protect from light and moisture, store in a cool and dry place. Keep out of the reach of children.