Dormitol 7.5 mg (Tablet)
Medicine Details
Category | Details |
---|---|
Generic | Midazolam |
Company | Square pharmaceuticals plc |
Also available as |
Indications
- Short-term treatment of insomnia
- Sedation in premedication before surgical or diagnostic procedures
Description
A sleep-inducing agent with rapid onset and short duration of action, exerting an anxiolytic, anticonvulsant, and muscle-relaxant effect
Pharmacology
Actions are mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), inducing sedating effect, relaxing skeletal muscles, and inducing sleep, anesthesia, and amnesia
Dosage & Administration
- Oral dosage for adults: 7.5-15 mg daily
- Intravenous administration for endoscopic or cardiovascular procedures: initial dose is approximately 2.5 mg in healthy adults
Interaction
Can enhance the central sedative effect of neuroleptics, tranquillizers, antidepressants, sleep-inducing drugs, analgesics, anaesthetics, antipsychotics, anxiolytics, antiepileptic drugs, and sedative antihistamines
Contraindications
Must not be given to patients with severe respiratory or hepatic insufficiency, myasthenia gravis, sleep apnea syndrome, or known hypersensitivity to benzodiazepines or any component of the product
Side Effects
- Drowsiness, confusion, fatigue, headache, and muscle weakness may occur at the start of therapy
- Fluctuations in vital signs including respiratory depression and variations in blood pressure and pulse rate have been noted following parenteral administration
Pregnancy & Lactation
Should be avoided during pregnancy unless no safer alternative, and should not be administered to breastfeeding mothers
Precautions & Warnings
Dormitol IV should be administered very slowly
Overdose Effects
Extreme overdosage may lead to coma, cardiorespiratory depression, and apnea, and can be controlled with benzodiazepine antagonist flumazenil
Therapeutic Class
- Benzodiazepine hypnotics
- Benzodiazepine sedatives
Storage Conditions
Protect from light and moisture, store in cool and dry place, keep out of the reach of children
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