Terminex 200 mg+200 mcg (Tablet)

Indications

• Early Menstrual Regulation (MR)
• Termination of pregnancy up to 9 weeks of gestation

Composition

• Box contains 2 blister strips
• 1 strip contains 1 tablet of Mifepristone INN 200 mg
• Another strip contains 4 tablets of Misoprostol USP 200 microgram each

Mode of Action

• Mifepristone has anti-progestational activity
• Mifepristone inhibits progesterone activity
• Misoprostol causes myometrial contraction

Dosage & Administration

• Mifepristone administration on Day 1
• Misoprostol administration on Day 2
• Post-treatment examination on Day 10 to 14

Interaction

• Mifepristone may be affected by Ketoconazole, Itraconazole, Erythromycin, and grapefruit juice
• Misoprostol does not interfere with aspirin effects

Contraindications

• Allergy to Mifepristone, Misoprostol, or prostaglandin
• Ectopic pregnancy
• Chronic adrenal failure
• Haemorrhagic disorders or concurrent anticoagulant therapy
• Inherited porphyria

Side Effects

• Nausea, vomiting, and diarrhea with Mifepristone
• Gastro-intestinal side-effects like diarrhea and abdominal pain with Misoprostol

Pregnancy & Lactation

• Mifepristone is indicated for Menstrual Regulation (MR)
• Mifepristone may lead to fetal malformation

Precautions & Warnings

• Combination of Mifepristone & Misoprostol is specific to the patient
• Intra Uterine Device [IUD] should be removed before treatment

Use in Special Populations

• Decreased dose of Misoprostol in patients with hepatic impairment
• No routine dosage adjustment in older patients or patients with renal impairment

Overdose Effects

• No serious adverse reactions reported in tolerance studies with Mifepristone
• Clinical signs of overdose for Misoprostol

Therapeutic Class

• Drugs acting on the Uterus
• Prostaglandin analogues

Storage Conditions

• Store in a cool and dry place
• Protected from light

Related Brands

• MTP Kit 200 mg+200 mcg (Tablet) - sharif-pharmaceuticals-ltd