Terminex 200 mg+200 mcg (Tablet)

(1+4) tablet kit: ৳ 300.00

Medicine Details

Indications

  • Early Menstrual Regulation (MR)
  • Termination of pregnancy up to 9 weeks of gestation

Composition

  • Box contains 2 blister strips
  • 1 strip contains 1 tablet of Mifepristone INN 200 mg
  • Another strip contains 4 tablets of Misoprostol USP 200 microgram each

Mode of Action

  • Mifepristone has anti-progestational activity
  • Mifepristone inhibits progesterone activity
  • Misoprostol causes myometrial contraction

Dosage & Administration

  • Mifepristone administration on Day 1
  • Misoprostol administration on Day 2
  • Post-treatment examination on Day 10 to 14

Interaction

  • Mifepristone may be affected by Ketoconazole, Itraconazole, Erythromycin, and grapefruit juice
  • Misoprostol does not interfere with aspirin effects

Contraindications

  • Allergy to Mifepristone, Misoprostol, or prostaglandin
  • Ectopic pregnancy
  • Chronic adrenal failure
  • Haemorrhagic disorders or concurrent anticoagulant therapy
  • Inherited porphyria

Side Effects

  • Nausea, vomiting, and diarrhea with Mifepristone
  • Gastro-intestinal side-effects like diarrhea and abdominal pain with Misoprostol

Pregnancy & Lactation

  • Mifepristone is indicated for Menstrual Regulation (MR)
  • Mifepristone may lead to fetal malformation

Precautions & Warnings

  • Combination of Mifepristone & Misoprostol is specific to the patient
  • Intra Uterine Device [IUD] should be removed before treatment

Use in Special Populations

  • Decreased dose of Misoprostol in patients with hepatic impairment
  • No routine dosage adjustment in older patients or patients with renal impairment

Overdose Effects

  • No serious adverse reactions reported in tolerance studies with Mifepristone
  • Clinical signs of overdose for Misoprostol

Therapeutic Class

  • Drugs acting on the Uterus
  • Prostaglandin analogues

Storage Conditions

  • Store in a cool and dry place
  • Protected from light

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