Trazapin 7.5 mg (Tablet)

Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Mirtazapine
Company Albion laboratories limited
Also available as
Trazapin 15 mg tablet Trazapin 30 mg tablet

Indications

  • Treatment of major depressive disorder (MDD)

Pharmacology

  • Mechanism of action is unknown
  • Enhances central noradrenergic and serotonergic activity
  • Acts as an antagonist at central presynaptic α2-adrenergic inhibitory autoreceptors and heteroreceptors
  • Antagonist of 5-HT<sub>2</sub> and 5-HT<sub>3</sub> receptors
  • Antagonist of histamine (H<sub>1</sub>) receptors
  • Moderate peripheral &alpha;1-adrenergic antagonist
  • Moderate antagonist at muscarinic receptors
  • Rapid and well-absorbed after oral administration
  • Mean half-life of elimination is 20-40 hours
  • Extensively metabolized and eliminated via the urine and faeces

Dosage & Administration

  • Recommended starting dose is 15 mg/day
  • Administered in a single dose, preferably in the evening or prior to sleep
  • Effective dose range is generally 15 to 45 mg/day
  • Dose changes should be made at intervals of less than 1 to 2 weeks
  • Not recommended for use in children
  • Instructions for missed dose

Interaction

  • Clinically significant drug-drug interactions with Monoamine Oxidase Inhibitors (MAOI) & other serotonergic drugs
  • May interrupt the metabolism or activity of Carbamazepine, Phenytoin or Cimetidine
  • Patients should avoid Alcohol & Diazepam

Contraindications

  • Contraindicated in patients with a known hypersensitivity to Mirtazapine or to any of the excipients
  • Concomitant use with a monoamine oxidase (MAO) inhibitor is contraindicated

Side Effects

  • Dizziness
  • Drowsiness
  • Dry mouth
  • Increased appetite
  • Weight gain

Pregnancy & Lactation

  • Pregnancy Category-C
  • Patients should notify their physician if they become pregnant or intend to become pregnant during therapy
  • Patients should notify their physician if they are breastfeeding an infant

Precautions & Warnings

  • Patients, families, and caregivers should be alert to the emergence of various symptoms
  • Patients should be warned about the risk of developing agranulocytosis
  • May impair judgment, thinking, and motor skills
  • Clinically significant ALT (SGPT) elevations may occur

Therapeutic Class

  • Atypical anti-depressant drugs

Storage Conditions

  • Keep away from light and moisture
  • Store below 30&ordm; C
  • Keep all medicine out of the reach of children

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