Mirapro 7.5 mg (Tablet)
Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Mirtazapine |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Treatment of major depressive disorder (MDD)
Pharmacology
- Enhances central noradrenergic and serotonergic activity
- Antagonist at central presynaptic α2-adrenergic inhibitory autoreceptors and heteroreceptors
- Antagonist of 5-HT2 and 5-HT3 receptors
- No significant affinity for the 5-HT1A and 5-HT1B receptors
- Potent antagonist of histamine (H1) receptors
- Moderate peripheral α1-adrenergic antagonist
- Moderate antagonist at muscarinic receptors
- Rapid and well-absorbed after oral administration
- Mean half-life of elimination is 20-40 hours
- Displays linear pharmacokinetics within the recommended dose range
- Metabolized and eliminated via the urine and faeces
Dosage & Administration
- Recommended starting dose of 15 mg/day
- Administered in a single dose, preferably in the evening or prior to sleep
- Effective dose range is generally 15 to 45 mg/day
- Dose changes should be made at intervals of less than 1 to 2 weeks
- Use in children is not recommended
- Instructions for missed doses
Interaction
- Clinically significant drug-drug interactions with MAOI & other serotonergic drugs
- May interrupt the metabolism or activity of Carbamazepine, Phenytoin or Cimetidine
- Patients should avoid Alcohol & Diazepam
Contraindications
- Contraindicated in patients with known hypersensitivity to Mirtazapine or its excipients
- Concomitant use of MAO inhibitor is contraindicated
Side Effects
- Common side effects include dizziness, drowsiness, dry mouth, increased appetite, weight gain
Pregnancy & Lactation
- Pregnancy Category-C
- Patients should notify their physician if they become pregnant or intend to become pregnant during therapy
- Patients should notify their physician if they are breastfeeding
Precautions & Warnings
- Patients should be alert to the emergence of certain behaviors and worsening of depression
- Warned about the risk of developing agranulocytosis
- May impair judgment, thinking, and motor skills
- Clinically significant ALT (SGPT) elevations may occur
Therapeutic Class
- Atypical anti-depressant drugs
Storage Conditions
- Keep away from light and moisture
- Store below 30°C
- Keep all medicine out of the reach of children