Amikast 10 mg (Tablet)

Title

• Amikast 10 mg Tablet

Categories

• Medicine
• Asthma Treatment
• Allergic Rhinitis Relief

Indications

• Prophylaxis and chronic treatment of asthma
• Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
• Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Pharmacology

• Selective and orally active leukotriene receptor antagonist
• Inhibition of cysteinyl leukotriene receptor (CysLT1)
• Correlation with the pathophysiology of asthma & allergic rhinitis
• Contributing to signs and symptoms of asthma such as airway edema and altered cellular activity

Dosage & Administration

• 10 mg tablet once daily for adults and adolescents 15 years of age and older
• 5 mg tablet once daily for pediatric patients 6 to 14 years of age
• 4 mg tablet once daily for pediatric patients 2 to 5 years of age
• 4 mg oral granules once daily for pediatric patients 6 months to 5 years of age

Use in Pediatric Patients

• Established safety and efficacy in pediatric patients with asthma 6 months to 14 years of age
• Similar safety and efficacy profiles to those in adults

Hepatic Insufficiency

• No dosage adjustment required for patients with mild-to-moderate hepatic insufficiency

Renal Insufficiency

• No dosage adjustment recommended for patients with renal insufficiency

Elderly Use

• Similar pharmacokinetic profile and oral bioavailability to younger adults
• Slightly longer plasma half-life in the elderly
• No dosage adjustment required for the elderly

Interaction

• No apparent increase in adverse reactions when administered with other asthma therapies
• No clinically important effects on the pharmacokinetics of specified drugs, including theophylline, prednisone, and oral contraceptives
• Used concomitantly with a wide range of commonly prescribed drugs without evidence of clinical adverse interactions

Contraindications

• Hypersensitivity to any component of this product

Side Effects

• Common: Diarrhoea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, upper respiratory tract infection
• Uncommon: Akathisia, anxiety, arthralgia, asthenia, depression, dizziness, dry mouth, malaise, muscle complaints, oedema, seizure, sleep disorders
• Rare: Angioedema, concentration impaired, hallucination, memory loss, palpitations, suicidal tendencies, tremor

Pregnancy & Lactation

• Crosses the placenta following oral dosing in rats and rabbits
• Caution advised when given to a nursing mother

Precautions & Warnings

• Not indicated for use in the reversal of bronchospasm in acute asthma attacks
• Appropriate rescue medication should be available
• Therapy can be continued during acute exacerbations of asthma
• Not to be abruptly substituted for inhaled or oral corticosteroids
• Not to be used as monotherapy for the treatment and management of exercise induced bronchospasm
• Caution in patients with known aspirin sensitivity

Overdose Effects

• No adverse experiences in the majority of overdosage reports
• Adverse experiences consistent with the safety profile of Amikast
• Usual supportive measures recommended in the event of overdose

Therapeutic Class

• Leukotriene receptor antagonists

Storage Conditions

• Store in cool & dry place below 30°C
• Protect from light & moisture
• Keep out of reach of children

Chemical Structure

• Molecular Formula: C35H36ClNO3S
• Chemical Structure image available

Commonly Asked Questions

• Use exactly as prescribed by the doctor
• Not a fast-acting rescue medicine for asthma attacks
• Caution advised in pregnant and breastfeeding women
• Avoid situations or activities that may trigger an asthma attack

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