Liam 5 mg (Chewable Tablet)

Indications

• Prophylaxis and chronic treatment of asthma
• Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
• Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Pharmacology

Montelukast is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene receptor (CysLT1). The cysteinyl leukotrienes (LTC4, LTD4, LTE4) are products of arachidonic acid metabolism and are released from various cells, including mast cells and eosinophils. Cysteinyl leukotrienes and leukotriene receptor occupation have been correlated with the pathophysiology of asthma & allergic rhinitis, including airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process.

Dosage & Administration

• Dosage for adults and adolescents 15 years of age and older: Montelukast 10 mg tablet once daily
• Dosage for pediatric patients 6 to 14 years of age: Montelukast 5 mg tablet once daily
• Dosage for pediatric patients 2 years to 5 years of age: Montelukast 4 mg tablet once daily
• Dosage for pediatric patients 6 months to 5 years of age: Montelukast 4 mg oral granules once daily

Interaction

Liam has been administered with other therapies routinely used in the prophylaxis and chronic treatment of asthma with no apparent increase in adverse reactions. In drug interaction studies, Liam did not have clinically important effects on the pharmacokinetics of several drugs.

Contraindications

Montelukast is contraindicated in patients who are hypersensitive to any component of this product.

Side Effects

• Common: Diarrhoea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, upper respiratory tract infection
• Uncommon: Akathisia, anxiety, arthralgia, asthenia, abnormal behavior, depression, dizziness, drowsiness, dry mouth, haemorrhage, irritability, malaise, muscle complaints, oedema, seizure, abnormal sensation, sleep disorders
• Rare: Angioedema, concentration impaired, disorientation, eosinophilic granulomatosis with polyangiitis, erythema nodosum, hallucination, hepatic disorders, memory loss, palpitations, pulmonary eosinophilia, suicidal tendencies, tremor

Pregnancy & Lactation

Montelukast crosses the placenta following oral dosing in rats and rabbits. Caution should be exercised when Liam is given to a nursing mother.

Precautions & Warnings

• Liam is not indicated for use in the reversal of bronchospasm in acute asthma attacks
• Patients should be advised to have appropriate rescue medication available
• Liam should not be abruptly substituted for inhaled or oral corticosteroids

Overdose Effects

There were no adverse experiences in the majority of overdosage reports. In the event of overdose, it is reasonable to employ the usual supportive measures; e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring, and institute supportive therapy, if required.

Therapeutic Class

Leukotriene receptor antagonists

Storage Conditions

Store in cool & dry place below 30°C, protect from light & moisture. Keep out of reach of children.

Chemical Structure

• Molecular Formula: C35H36ClNO3S
• Chemical Structure Image: https://medex.com.bd/storage/res/g-res-768-montelukast-sodium-chemical-structure-drK1lRHjspWQ7613gJoZ.svg

Common Questions about Liam 5 mg Chewable Tablet

• Liam 5 mg Chew. Tablet is a selective and orally active leukotriene receptor antagonist
• Liam 5 mg Chew. Tablet is commonly used to treat asthma or allergic rhinitis
• The effect of Liam 5 mg Chew. Tablet can be observed after 1-3 hours of administration
• The effect of Liam 5 mg Chew. Tablet lasts for an average duration of 24 hours
• Liam 5 mg Chew. Tablet may be taken with or without food as prescribed by your doctor
• Use of Liam 5 mg Chew. Tablet in pregnant women should be avoided unless clearly needed
• General Instructions: Take Liam 5 mg Chew. Tablet exactly as prescribed by your doctor, do not change your Liam 5 mg Chew. Tablet dose or stop using asthma medication without your doctor's advice, avoid situations or activities that may trigger an asthma attack, talk to your doctor before using Liam 5 mg Chew. Tablet if you're pregnant or breastfeeding

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