Paricel 10 mg (Tablet (Enteric Coated))

Unit Price: ৳ 3.51 (10 x 10: ৳ 351.00)
Strip Price: ৳ 35.10

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Aci limited
Also available as
Paricel 20 mg tablet Paricel 20 mg capsule

Indications

  • Treatment of active duodenal ulcer
  • Treatment of active benign gastric ulcer
  • Treatment of symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Gastro-esophageal Reflux Disease Long-term Management (GERD Maintenance)
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Treatment of Zollinger-Ellison Syndrome
  • In combination with antibacterial therapeutic regimens for the eradication of Helicobacter pylori

Pharmacology

  • Suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase

Dosage

  • Recommended oral dose for active duodenal ulcer and active benign gastric ulcer is 20 mg once daily in the morning
  • Recommended oral dose for erosive or ulcerative gastro-esophageal reflux disease (GERD) is 20 mg once daily for four to eight weeks
  • Maintenance dose of rabeprazole sodium 20 mg or 10 mg once daily for long-term management of GERD
  • Treatment of GERD in pediatric patients 1 to 11 years of age: 5 mg or 10 mg once daily for 12 weeks
  • Starting dose of 60 mg once a day for Zollinger-Ellison Syndrome
  • Combination therapy for H. pylori eradication: Rabeprazole sodium 20 mg twice daily for 7 days

Administration

  • Tablets to be taken in the morning before eating
  • Should be swallowed whole and not chewed or crushed

Interaction

  • May interact with compounds whose absorption is pH dependent
  • Co-administration with ketoconazole or itraconazole may decrease antifungal plasma levels
  • No interaction with liquid antacids observed
  • Not recommended to be co-administered with atazanavir

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Contra-indicated in pregnancy and during breastfeeding

Side Effects

  • May cause headache, diarrhea, abdominal pain, vomiting, constipation, dry mouth, changes in appetite, muscle pain, drowsiness, and dizziness

Pregnancy & Lactation

  • US FDA pregnancy category 'C'
  • Insufficient data for pregnant women, likely excreted in human milk

Precautions & Warnings

  • Possibility of gastric or esophageal malignancy should be excluded prior to commencement of treatment
  • Regular surveillance for patients on long-term treatment
  • Possible increase in bone fracture risk in the elderly or with long-term use
  • Risk of cross-hypersensitivity reactions with other proton pump inhibitors
  • Caution for patients with osteoporosis and hypomagnesaemia
  • Risk of gastrointestinal infections such as Salmonella, Campylobacter, and Clostridium difficile
  • Interference with investigations for neuroendocrine tumors
  • Consideration for vitamin B12 absorption and subacute cutaneous lupus erythematosus (SCLE)
  • No dosage adjustment for patients with renal or hepatic impairment

Use in Special Populations

  • No dosage adjustment necessary for patients with renal or hepatic impairment
  • Not recommended for use in children due to lack of safety and efficacy data

Overdose Effects

  • Maximum established exposure is 60 mg twice daily or 160 mg once daily
  • Effects generally minimal and reversible without further medical intervention

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep below 30°C, away from light and moisture, out of reach of children

Chemical Structure

  • Molecular Formula: C18H21N3O3S

Common Questions

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