Centokast 10 mg (Tablet)

Indications

• Prophylaxis and chronic treatment of asthma
• Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
• Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Pharmacology

• Montelukast is a selective and orally active leukotriene receptor antagonist
• Inhibits the cysteinyl leukotriene receptor (CysLT1)
• Correlated with the pathophysiology of asthma & allergic rhinitis
• Contributes to signs and symptoms of asthma such as airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process

Dosage & Administration

• Dosage for adults and adolescents 15 years of age and older: Montelukast 10 mg tablet once daily
• Dosage for pediatric patients 6 to 14 years of age: Montelukast 5 mg tablet once daily
• Dosage for pediatric patients 2 years to 5 years of age: Montelukast 4 mg tablet once daily
• Pediatric patients 6 months to 5 years of age: Montelukast 4 mg oral granules once daily
• Safety and efficacy of Montelukast established in pediatric patients with asthma 6 months to 14 years of age
• No dosage adjustment required in patients with mild-to-moderate hepatic insufficiency
• No dosage adjustment recommended in patients with renal insufficiency
• Pharmacokinetic profile and the oral bioavailability of a single 10-mg oral dose of montelukast are similar in elderly and younger adults

Interaction

• No apparent increase in adverse reactions when administered with other therapies routinely used in the prophylaxis and chronic treatment of asthma
• No clinically important effects on the pharmacokinetics of theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin, and warfarin
• Used concomitantly with a wide range of commonly prescribed drugs without evidence of clinical adverse interactions
• Phenobarbital decreased the AUC of Centokast approximately 40% following a single 10mg dose
• No dosage adjustment for Centokast is recommended

Contraindications

• Hypersensitivity to any component of this product

Side Effects

• Common: Diarrhoea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, upper respiratory tract infection
• Uncommon: Akathisia, anxiety, arthralgia, asthenia, abnormal behavior, depression, dizziness, drowsiness, dry mouth, haemorrhage, irritability, malaise, muscle complaints, oedema, seizure, abnormal sensation, sleep disorders
• Rare: Angioedema, concentration impaired, disorientation, eosinophilic granulomatosis with polyangiitis, erythema nodosum, hallucination, hepatic disorders, memory loss, palpitations, pulmonary eosinophilia, suicidal tendencies, tremor

Pregnancy & Lactation

• Should be used during pregnancy only if clearly needed
• Caution should be exercised when given to a nursing mother

Precautions & Warnings

• Not indicated for use in the reversal of bronchospasm in acute asthma attacks
• Appropriate rescue medication should be available
• Therapy can be continued during acute exacerbations of asthma
• Centokast should not be abruptly substituted for inhaled or oral corticosteroids
• Not to be used as monotherapy for the treatment and management of exercise induced bronchospasm
• Patients with known aspirin sensitivity should continue avoidance of aspirin or non-steroidal anti-inflammatory agents while taking Centokast

Overdose Effects

• No adverse experiences in the majority of overdosage reports
• Usual supportive measures should be employed in the event of overdose

Therapeutic Class

• Leukotriene receptor antagonists

Storage Conditions

• Store in cool & dry place below 30°C
• Protect from light & moisture
• Keep out of reach of children

Chemical Structure

• Molecular Formula: C35H36ClNO3S

Common Questions about Centokast 10 mg Tablet

• Selective and orally active leukotriene receptor antagonist
• Used to treat asthma or allergic rhinitis
• Effect can be observed after 1-3 hours of administration
• Effect lasts for an average duration of 24 hours
• May be taken with or without food as prescribed by a doctor
• Use in pregnant women should be avoided unless clearly needed
• Take exactly as prescribed by a doctor
• Do not change the dose or stop using asthma medication without doctor's advice
• Not a fast-acting rescue medicine for asthma attacks

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