Paricel 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.00 (8 x 10: ৳ 640.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Aci limited
Also available as
Paricel 20 mg tablet Paricel 10 mg tablet

Title

Paricel Gastro-resistant Tablets

Categories

  • Medicine
  • Gastrointestinal Health
  • Digestive System

Description

Rabeprazole is a proton pump inhibitor indicated for the treatment of conditions such as active duodenal ulcer, active benign gastric ulcer, GERD, Zollinger-Ellison Syndrome, and H. pylori eradication, among others.

Indication

  • Active duodenal ulcer
  • Active benign gastric ulcer
  • GERD
  • Zollinger-Ellison Syndrome
  • H. pylori eradication

Pharmacology

Rabeprazole suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase at the secretory surface of the gastric parietal cell.

Dosage

  • ActiveDuodenalUlcerAndBenignGastricUlcer: 20 mg once daily in the morning
  • EruptiveOrUlcerativeGERD: 20 mg once daily for 4-8 weeks
  • GERDMaintenance:
    • 20 mg or 10 mg once daily
  • SymptomaticGERD: 10 mg once daily
  • ZollingerEllisonSyndrome: 60 mg once daily, titrate up to 120 mg/day based on individual patient needs
  • EradicationOfHPylori: 20 mg twice daily in combination with other antibiotics

Administration

Tablets should be taken in the morning, before eating, and should not be chewed or crushed.

Interaction

  • Interacts with compounds having pH-dependent absorption
  • Potential decrease in plasma levels when co-administered with ketoconazole or itraconazole
  • No interaction with liquid antacids
  • Should not be co-administered with atazanavir

Contraindications

  • Hypersensitivity to the active substance or any of the excipients
  • Contraindicated in pregnancy and during breastfeeding

SideEffects

  • Headache
  • Diarrhoea
  • Abdominal pain
  • Vomiting
  • Constipation
  • Dry mouth
  • Increased or decreased appetite
  • Muscle pain
  • Drowsiness
  • Dizziness

PregnancyAndLactation

US FDA pregnancy category 'C'. No adequate and well-controlled studies in pregnant women. Likely excreted in human milk.

PrecautionsAndWarnings

  • GastricOrOesophagealMalignancy: Possibility should be excluded prior to treatment
  • LongTermTreatment: Patients on long-term treatment should be kept under regular surveillance
  • RiskOfFracture: May increase risk of hip, wrist, and spine fracture, especially in the elderly or with other risk factors
  • CrossHypersensitivityReactions: A risk of cross-hypersensitivity reactions with other proton pump inhibitors or substituted benzimidazoles cannot be excluded
  • Hypomagnesaemia: Severe hypomagnesaemia has been reported in patients treated with PPIs for at least three months
  • InfluenceOnVitaminB12Absorption: May reduce the absorption of vitamin B12
  • SCLE: Proton pump inhibitors are associated with very infrequent cases of subacute cutaneous lupus erythematosus
  • InterferenceWithLabTests: Increased Chromogranin A level may interfere with investigations for neuroendocrine tumours

SpecialPopulations

  • RenalAndHepaticImpairment: No dosage adjustment necessary
  • PediatricPopulations: Not recommended due to a lack of data on safety and efficacy

OverdoseEffects

Effects are generally minimal, representative of the known adverse event profile and reversible without further medical intervention. No specific antidote is known.

TherapeuticClass

Proton Pump Inhibitor

StorageConditions

Keep below 30°C, away from light and moisture, and out of the reach of children

ChemicalStructure

Molecular Formula: C18H21N3O3S

CommonQuestions

  • Uses: Used to treat Duodenal ulcer, Gastric ulcer, GERD, Zollinger-Ellison Syndrome, Helicobacter pylori eradication
  • SideEffects: Common side effects include diarrhea, constipation, nausea, and vomiting
  • Overdose: If overdosed, call doctor or Poison Control Center. Effects are generally reversible without medical intervention

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