Xyflo 5 mg (Chewable Tablet)

Unit Price: ৳ 11.00 (3 x 10: ৳ 330.00)
Strip Price: ৳ 110.00

Medicine Details

Category Details
Generic Montelukast sodium
Company Radiant pharmaceuticals ltd
Also available as
Xyflo 10 mg tablet Xyflo 4 mg chewable tablet

ProductTitle

Xyflo 5 mg Chewable Tablet

Categories

  • Asthma Medication
  • Allergic Rhinitis Medication
  • Leukotriene Receptor Antagonist

Description

Xyflo 5 mg Chewable Tablet is indicated for the prophylaxis and chronic treatment of asthma, acute prevention of Exercise-Induced Bronchoconstriction (EIB), and relief of symptoms of Allergic Rhinitis (AR) including Seasonal & Perennial Allergic Rhinitis. It contains Montelukast, a leukotriene receptor antagonist that inhibits the cysteinyl leukotriene receptor (CysLT1), and is used in adult, adolescent, and pediatric patients. The medication has specific dosages based on age groups, with potential adverse effects and precautions to consider. Montelukast crosses the placenta and cautions should be exercised during pregnancy and lactation.

Indication

  • Prophylaxis and chronic treatment of asthma
  • Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
  • Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Pharmacology

Montelukast is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene receptor (CysLT1). It affects the pathophysiology of asthma & allergic rhinitis, including airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process.

DosageAndAdministration

  • AdultsAndAdolescents: Montelukast 10 mg tablet once daily
  • PediatricPatients:
    • 6 to 14 years: Montelukast 5 mg tablet once daily
    • 2 to 5 years: Montelukast 4 mg tablet once daily
    • 6 months to 5 years: Montelukast 4 mg oral granules once daily
  • SpecialPopulations:
    • HepaticInsufficiency: No dosage adjustment required
    • RenalInsufficiency: No dosage adjustment recommended
    • ElderlyUse: Similar pharmacokinetic profile to younger adults; plasma half-life slightly longer in the elderly

Interactions

  • NoClinicallyImportantEffects:
    • Theophylline
    • Prednisone
    • Prednisolone
    • Oral contraceptives
    • Terfenadine
    • Digoxin
    • Warfarin
  • UsedConcomitantlyWith:
    • Thyroid hormones
    • Sedative hypnotics
    • Non-steroidal anti-inflammatory agents
    • Benzodiazepines
    • Decongestants
  • DecreasedAUCWith: Phenobarbital
  • Recommendations: No dosage adjustment recommended; appropriate clinical monitoring when potent cytochrome P450 enzyme inducers are co-administered

Contraindications

  • Hypersensitivity to any component of the product

SideEffects

  • Common:
    • Diarrhoea
    • Fever
    • Gastrointestinal discomfort
    • Headache
    • Nausea
    • Vomiting
    • Skin reactions
    • Upper respiratory tract infection
  • Uncommon:
    • Akathisia
    • Anxiety
    • Arthralgia
    • Asthenia
    • Abnormal behavior
    • Depression
    • Dizziness
    • Drowsiness
    • Dry mouth
    • Haemorrhage
    • Irritability
    • Malaise
    • Muscle complaints
    • Oedema
    • Seizure
    • Abnormal sensation
    • Sleep disorders
  • Rare:
    • Angioedema
    • Concentration impaired
    • Disorientation
    • Hallucination
    • Hepatic disorders
    • Memory loss
    • Palpitations
    • Pulmonary eosinophilia
    • Suicidal tendencies
    • Tremor

PregnancyAndLactation

  • InPregnantWomen: To be used only if clearly needed
  • NursingMothers: Caution should be exercised

PrecautionsAndWarnings

  • NotForReversalOfBronchospasm: Not indicated for use in the reversal of bronchospasm in acute asthma attacks
  • AppropriateRescueMedication: Patients should have appropriate rescue medication available
  • ContinuedUseDuringExacerbations: Therapy can be continued during acute exacerbations of asthma
  • AvoidAbruptSubstitution: Should not be abruptly substituted for inhaled or oral corticosteroids
  • AsMonotherapyForEIB: Should not be used as monotherapy for the treatment and management of exercise induced bronchospasm
  • AspirinSensitivity: Continue avoidance of aspirin or non-steroidal anti-inflammatory agents
  • EffectInImprovingAirwayFunction: Effective in improving airway function in asthmatics with documented aspirin sensitivity but has not been shown to truncate bronchoconstrictor response to aspirin and other non-steroidal anti-inflammatory drugs

OverdoseEffects

  • AdverseExperiences: No adverse experiences in the majority of overdosage reports
  • FrequentlyOccurringAdverseExperiences:
    • Abdominal pain
    • Somnolence
    • Thirst
    • Headache
    • Vomiting
    • Psychomotor hyperactivity
  • SupportiveMeasures: Usual supportive measures recommended in the event of overdose

TherapeuticClass

Leukotriene receptor antagonists

StorageConditions

Store in cool & dry place below 30°C, protect from light & moisture, keep out of reach of children

ChemicalStructure

  • MolecularFormula: C35H36ClNO3S
  • ChemicalStructureImage: https://medex.com.bd/storage/res/g-res-768-montelukast-sodium-chemical-structure-drK1lRHjspWQ7613gJoZ.svg

CommonQuestions

  • Description: Common questions about Xyflo 5 mg Chewable Tablet
  • QuestionsAndAnswers:
      • Question: What is Xyflo 5 mg Chew. Tablet?
      • Answer: A selective and orally active leukotriene receptor antagonist.
      • Question: What is Xyflo 5 mg Chew. Tablet used for?
      • Answer: Commonly used to treat asthma or allergic rhinitis, helps keep airways open and easy breathing by blocking leukotrienes.
      • Question: How soon can the effect be observed?
      • Answer: The effect can be observed after 1-3 hours of administration, not a fast-acting rescue medicine for asthma attacks and needs to be taken daily to work properly.
      • Question: How long does the effect last?
      • Answer: Lasts for an average duration of 24 hours.
      • Question: Should I use it on an empty stomach?
      • Answer: May be taken with or without food as prescribed by your doctor.
      • Question: What if I miss a dose?
      • Answer: If you miss a dose, you may take it as soon as possible. But if it is almost time for your next dose, just skip that dose. Do not double up on doses.
      • Question: Any pregnancy warnings?
      • Answer: Use should be avoided in pregnant women unless clearly needed.
      • Question: General Instructions
      • Answer: Take exactly as prescribed, do not change dose or stop using asthma medication without doctor's advice. Not a fast-acting rescue medicine for asthma attacks. Avoid trigger situations or activities. Consult doctor if pregnant or breastfeeding.

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