Rabeprol 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 5.75 (6 x 10: ৳ 345.00)
Strip Price: ৳ 57.50

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Somatec pharmaceuticals ltd
Also available as
Rabeprol 20 mg capsule Rabeprol 10 mg capsule

Indications

  • Treatment of active duodenal ulcer
  • Treatment of active benign gastric ulcer
  • Symptomatic treatment of erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Long-term management of gastro-esophageal reflux disease (GERD)
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Treatment of Zollinger-Ellison Syndrome
  • Eradication of Helicobacter pylori in patients with peptic ulcer disease

Pharmacology

  • Suppresses gastric acid secretion
  • Inhibits the gastric H+/K+-ATPase
  • Characterized as a gastric proton-pump inhibitor

Dosage

  • Recommended oral dose for active duodenal ulcer and active benign gastric ulcer is 20 mg once daily in the morning
  • Recommended oral dose for erosive or ulcerative gastro-esophageal reflux disease is 20 mg once daily for four to eight weeks
  • Maintenance dose of rabeprazole sodium 20 mg or 10 mg once daily for long-term management
  • Initial adult starting dose for Zollinger-Ellison Syndrome is 60 mg once a day, with possible titration upwards to 120 mg/day based on individual patient needs
  • Recommended combination for eradication of Helicobacter pylori: Rabeprazole sodium 20 mg twice daily, clarithromycin 500 mg twice daily, and amoxicillin 1g twice daily for 7 days

Administration

  • Rabeprazole tablets should be taken in the morning before eating
  • Tablets should not be chewed or crushed, but swallowed whole

Interaction

  • Potential interaction with compounds whose absorption is pH dependent
  • Co-administration with ketoconazole or itraconazole may decrease antifungal plasma levels
  • No interaction observed with liquid antacids
  • PPIs including rabeprazole should not be co-administered with atazanavir

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Contra-indicated in pregnancy and during breastfeeding

Side Effects

  • May cause headache, diarrhea, abdominal pain, vomiting, constipation, dry mouth, increased or decreased appetite, muscle pain, drowsiness, and dizziness

Pregnancy & Lactation

  • US FDA pregnancy category 'C'
  • No adequate and well-controlled studies in pregnant women
  • Likely excretion in human milk

Precautions & Warnings

  • Symptomatic response to therapy with Rabeprol does not exclude the presence of gastric or esophageal malignancy
  • Patients on long-term treatment should be kept under regular surveillance
  • Proton pump inhibitors may modestly increase the risk of hip, wrist, and spine fracture
  • Risk of cross-hypersensitivity reactions with other proton pump inhibitors or substituted benzimidazoles
  • Rabeprazole may reduce the absorption of vitamin B12
  • May increase the risk of gastrointestinal infections such as Salmonella and Clostridium difficile
  • Risk of hypomagnesaemia, hepatic enzyme abnormalities, and interference with laboratory tests

Use in Special Populations

  • No dosage adjustment necessary for patients with renal or hepatic impairment
  • Not recommended for use in children due to lack of data on safety and efficacy

Overdose Effects

  • Maximum established exposure has not exceeded 60 mg twice daily or 160 mg once daily
  • Effects are generally minimal, representative of known adverse event profile, and reversible without further medical intervention
  • No specific antidote is known

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep below 30°C temperature, away from light and moisture
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C18H21N3O3S

Common Questions about Rabeprol 20 mg Tablet

  • Is a proton pump inhibitor (PPI) that suppresses gastric acid secretion
  • Used to treat duodenal ulcer, gastric ulcer, GERD, Zollinger-Ellison Syndrome, and Helicobacter pylori eradication
  • Common side effects include diarrhea, constipation, nausea, vomiting, headache, dizziness, rash, and dry mouth
  • Should be taken with food, with the usual dose being one tablet once a day
  • Not recommended for use during pregnancy or breastfeeding
  • Overdose can cause symptoms such as drowsiness, confusion, and seizures

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