Tekast 10 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Montelukast sodium |
| Company | Team pharmaceuticals ltd |
| Also available as |
Title
Tekast 10 mg Tablet
Categories
- Asthma Treatment
- Allergic Rhinitis Treatment
- Leukotriene Receptor Antagonist
Description
Tekast 10 mg Tablet is indicated for prophylaxis and chronic treatment of asthma, acute prevention of Exercise-Induced Bronchoconstriction (EIB), relief of symptoms of Allergic Rhinitis (AR) including seasonal & perennial AR. It is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene receptor (CysLT1). The recommended dosage for adults and adolescents is Montelukast 10 mg tablet once daily, for pediatric patients 6 to 14 years of age is Montelukast 5 mg tablet once daily, and for pediatric patients 2 years to 5 years of age is Montelukast 4 mg tablet once daily. The medication has been studied in pediatric patients with asthma 6 months to 14 years of age. No dosage adjustment is required in patients with mild-to-moderate hepatic insufficiency or renal insufficiency. The product is contraindicated in patients who are hypersensitive to any component of the product. Common side effects include diarrhea, fever, headache, nausea, vomiting, and upper respiratory tract infection. Tekast should be stored in a cool & dry place below 30°C, protected from light & moisture, and kept out of reach of children. It crosses the placenta following oral dosing in rats and rabbits but caution should be exercised when given to a nursing mother. Montelukast is not indicated for use in the reversal of bronchospasm in acute asthma attacks. There are no adverse experiences in the majority of overdosage reports, but in the event of overdose, the usual supportive measures should be employed.
Dosage and Administration
- Montelukast 10 mg tablet once daily for adults and adolescents
- Montelukast 5 mg tablet once daily for pediatric patients 6 to 14 years of age
- Montelukast 4 mg tablet once daily for pediatric patients 2 to 5 years of age
- Montelukast 4 mg oral granules once daily for pediatric patients 6 months to 5 years of age
Pharmacological Action
- Leukotriene receptor antagonist
- Inhibits cysteinyl leukotriene receptor (CysLT1)
Age-specific Dosage
- Pediatric patients 6 to 14 years of age
- Pediatric patients 2 to 5 years of age
- Pediatric patients 6 months to 5 years of age
Safety Profile
- Similar safety and efficacy in pediatric patients 6 months to 14 years of age as in adults
- No dosage adjustment needed in patients with mild-to-moderate hepatic insufficiency
- No dosage adjustment recommended in patients with renal insufficiency
Contraindications
- Hypersensitivity to any component of the product
Side Effects
- Diarrhea
- Fever
- Gastrointestinal discomfort
- Headache
- Nausea
- Vomiting
- Skin reactions
- Upper respiratory tract infection
- Akathisia
- Anxiety
- Arthralgia
- Asthenia
- Abnormal behavior
- Depression
- Dizziness
- Drowsiness
- Dry mouth
- Hemorrhage
- Irritability
- Malaise
- Muscle complaints
- Edema
- Seizure
- Abnormal sensation
- Sleep disorders
- Angioedema
- Impaired concentration
- Disorientation
- Eosinophilic granulomatosis with polyangiitis
- Erythema nodosum
- Hallucination
- Hepatic disorders
- Memory loss
- Palpitations
- Pulmonary eosinophilia
- Suicidal tendencies
- Tremor
Pregnancy and Lactation
- Crosses the placenta in rats and rabbits
- Caution advised in use during pregnancy
- Caution advised when given to a nursing mother
Precautions and Warnings
- Not indicated for use in the reversal of bronchospasm in acute asthma attacks
- Appropriate rescue medication should be available
- Can be continued during acute exacerbations of asthma
- Should not be abruptly substituted for inhaled or oral corticosteroids
- Not to be used as monotherapy for the treatment of exercise induced bronchospasm
- Patients with known aspirin sensitivity should continue avoidance of aspirin or non-steroidal anti-inflammatory agents while taking Tekast
- Not shown to truncate bronchoconstrictor response to aspirin and other non-steroidal anti-inflammatory drugs in aspirin-sensitive asthmatic patients
Drug Interaction
- No clinically important effects on the pharmacokinetics of theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin, and warfarin
- Used concomitantly with a wide range of commonly prescribed drugs in clinical studies without evidence of clinical adverse interactions
- Phenobarbital decreased the AUC of Tekast approximately 40%
- Clinical monitoring recommended when potent cytochrome P450 enzyme inducers are co-administered with Tekast
Overdose Effects
- Abdominal pain
- Somnolence
- Thirst
- Headache
- Vomiting
- Psychomotor hyperactivity
Common Questions
- What is Tekast 10 mg Tablet?
- What is Tekast 10 mg Tablet used for?
- How soon can the effect of Tekast 10 mg Tablet be observed?
- How long does the effect of Tekast 10 mg Tablet last?
- Should I use Tekast 10 mg Tablet empty stomach?
- What if I miss a dose of Tekast 10 mg Tablet?
- Are there any pregnancy warnings for Tekast 10 mg Tablet?
Additional Instructions
- Take Tekast 10 mg Tablet exactly as prescribed by the doctor
- Do not change the dosage or stop using asthma medication without the doctor's advice
- Avoid situations or activities that may trigger an asthma attack
- Talk to the doctor before using Tekast 10 mg Tablet if pregnant or breastfeeding
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