Antaluk 10 mg (Tablet)

Unit Price: ৳ 15.00 (2 x 10: ৳ 300.00)
Strip Price: ৳ 150.00

Medicine Details

Category Details
Generic Montelukast sodium
Company United pharmaceuticals ltd

Title and Category

  • Antaluk 10 mg Tablet
  • Medicine

Indications

  • Prophylaxis and chronic treatment of asthma
  • Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
  • Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Pharmacology

  • Montelukast is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene receptor (CysLT1)
  • Cysteinyl leukotrienes and leukotriene receptor occupation have been correlated with the pathophysiology of asthma & allergic rhinitis

Dosage & Administration

  • Adult dosage: Montelukast 10 mg tablet once daily
  • Pediatric dosage: 6 to 14 years - 5 mg tablet once daily, 2 to 5 years - 4 mg tablet once daily, 6 months to 5 years - 4 mg oral granules once daily

Hepatic and Renal Insufficiency

  • No dosage adjustment required

Elderly Use

  • Pharmacokinetic profile and oral bioavailability is similar to younger adults
  • Slightly longer plasma half-life in the elderly

Drug Interactions

  • No clinically important effects on the pharmacokinetics of multiple drugs
  • Concomitant use with a wide range of commonly prescribed drugs without evidence of adverse interactions
  • Phenobarbital decreased the AUC of Antaluk by approximately 40%

Contraindications

  • Hypersensitivity to any component of the product

Common Side Effects

  • Diarrhoea
  • Fever
  • Gastrointestinal discomfort
  • Headache
  • Nausea
  • Vomiting
  • Skin reactions
  • Upper respiratory tract infection

Uncommon Side Effects

  • Akathisia
  • Anxiety
  • Arthralgia
  • Asthenia
  • Abnormal behavior
  • Depression
  • Dizziness
  • Drowsiness
  • Dry mouth

Rare Side Effects

  • Angioedema
  • Concentration impaired
  • Disorientation
  • Eosinophilic granulomatosis with polyangiitis
  • Erythema nodosum
  • Hallucination
  • Hepatic disorders
  • Memory loss

Pregnancy & Lactation

  • Use during pregnancy only if clearly needed
  • Caution should be exercised when given to a nursing mother

Precautions & Warnings

  • Not indicated for use in the reversal of bronchospasm in acute asthma attacks
  • Should not be abruptly substituted for inhaled or oral corticosteroids
  • Not to be used as monotherapy for the treatment and management of exercise induced bronchospasm

Overdose Effects

  • No adverse experiences in the majority of reports
  • Usual supportive measures recommended in the event of overdose

Therapeutic Class

  • Leukotriene receptor antagonists

Storage Conditions

  • Store in cool & dry place below 30°C
  • Protect from light & moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C35H36ClNO3S

Commonly Asked Questions

  • Antaluk 10 mg Tablet is a selective and orally active leukotriene receptor antagonist
  • Used for the treatment of asthma or allergic rhinitis
  • Effect can be observed after 1-3 hours of administration
  • Effect lasts for an average duration of 24 hours
  • May be taken with or without food
  • Use during pregnancy should be avoided unless clearly needed
  • General instructions for usage

Usability Features

  • Block leukotrienes to keep airways open
  • Help in easy breathing
  • Not a fast-acting rescue medicine for asthma attacks

Dosage for Different Age Groups

  • Adult: 10 mg tablet once daily
  • 6-14 years: 5 mg tablet once daily
  • 2-5 years: 4 mg tablet once daily
  • 6 months-5 years: 4 mg oral granules once daily
  • No dosage adjustment for hepatic and renal insufficiency

Interaction with Other Therapies

  • No apparent increase in adverse reactions
  • Clinical dose did not have clinically important effects on the pharmacokinetics of multiple drugs
  • Used concomitantly with a wide range of commonly prescribed drugs without evidence of clinical adverse interactions

Side Effects Severity

  • Common
  • Uncommon
  • Rare

Storage Instructions

  • Keep in a cool and dry place below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Pregnancy and Lactation Caution

  • Use during pregnancy only if clearly needed
  • Caution should be exercised when given to a nursing mother

Pharmacological Action

  • Selective and orally active leukotriene receptor antagonist
  • Inhibits the cysteinyl leukotriene receptor (CysLT1)
  • Correlated with the pathophysiology of asthma & allergic rhinitis

Chemical Composition

  • Molecular Formula: C35H36ClNO3S

Usability Recommendations

  • Continue therapy during acute exacerbations of asthma
  • Do not abruptly substitute for inhaled or oral corticosteroids
  • Not to be used as monotherapy for the treatment and management of exercise induced bronchospasm

Interaction with Other Drugs

  • No clinically important effects on the pharmacokinetics of multiple drugs
  • Concomitant use with a wide range of commonly prescribed drugs without evidence of adverse interactions
  • Phenobarbital decreased the AUC of Antaluk by approximately 40%

Side Effects Management

  • Common and uncommon side effects may include gastrointestinal discomfort, headache, and nausea
  • In the event of overdose, recommend the usual supportive measures

Usage Precautions

  • Not indicated for use in the reversal of bronchospasm in acute asthma attacks
  • Not to be used as monotherapy for the treatment and management of exercise induced bronchospasm
  • Avoid abrupt substitution for inhaled or oral corticosteroids

Elderly Use Recommendations

  • No dosage adjustment required
  • Similar pharmacokinetic profile and oral bioavailability to younger adults

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