Rabifast 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 7.00 (5 x 14: ৳ 490.00)
Strip Price: ৳ 98.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Eskayef pharmaceuticals ltd

Title

  • Rabifast 20 mg Tablet

Categories

  • Medicines
  • Health & Wellness

Description

  • Rabifast Gastro-resistant tablets for the treatment of indications such as active duodenal ulcer, active benign gastric ulcer, gastro-esophageal reflux disease, Zollinger-Ellison Syndrome, and more.
  • Rabeprazole suppresses gastric acid secretion, characterized as a gastric proton-pump inhibitor.
  • Dosage recommendations for various conditions including duodenal ulcer, gastric ulcer, GERD, long-term management, symptomatic treatment, pediatric patients, Zollinger-Ellison Syndrome, and Helicobacter pylori eradication.
  • Administration instructions: to be taken in the morning, before eating, and swallowed whole.
  • Interactions with compounds such as ketoconazole, itraconazole, liquid antacids, and atazanavir.
  • Contraindications for individuals with hypersensitivity to the active substance or excipients, and contra-indication in pregnancy and during breastfeeding.
  • Common side effects including headache, diarrhea, abdominal pain, vomiting, constipation, dry mouth, changes in appetite, muscle pain, drowsiness, and dizziness.
  • US FDA pregnancy category, excretion in human milk, and considerations for use during pregnancy and lactation.
  • Precautions, warnings, and risks related to proton pump inhibitors, cross-hypersensitivity reactions, blood dyscrasias, hepatic enzyme abnormalities, hypomagnesaemia, vitamin B12 absorption, subacute cutaneous lupus erythematosus, interference with laboratory tests, and influence on gastrointestinal infections.
  • Use in special populations, with considerations for renal and hepatic impairment, and lack of recommendation for use in children.
  • Effects of overdose, reversible without further medical intervention, and storage conditions below 30°C, away from light & moisture.
  • Chemical structure: Molecular Formula C18H21N3O3S, and a Chemical Structure image.
  • Common questions about the product including its use, side effects, dosage, use during pregnancy or breastfeeding, overdose effects, duration of treatment, precautions, and potential bone problems when using the product for a prolonged period.

Indications

  • Active duodenal ulcer
  • Active benign gastric ulcer
  • Symptomatic erosive or ulcerative gastro-esophageal reflux disease
  • Gastro-esophageal Reflux Disease Long-term Management
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Zollinger-Ellison Syndrome
  • Combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori in patients with peptic ulcer disease

Pharmacology

  • Suppresses gastric acid secretion
  • Inhibits the gastric H+/K+-ATPase at the secretory surface of the gastric parietal cell
  • Characterized as a gastric proton-pump inhibitor

Dosage

  • Recommended oral dose for active duodenal ulcer and active benign gastric ulcer: 20 mg once daily in the morning
  • Recommended oral dose for erosive or ulcerative gastro-esophageal reflux disease: 20 mg once daily for four to eight weeks
  • Maintenance dose for long-term management: 20 mg or 10 mg once daily depending upon patient response
  • Recommended dose for Zollinger-Ellison Syndrome: 60 mg once a day, titrated upwards to 120 mg/day based on individual patient needs
  • Treatment regimen for eradication of H. pylori: Rabeprazole sodium 20 mg twice daily, clarithromycin 500 mg twice daily, and amoxicillin 1g twice daily for 7 days
  • Specific dosage recommendations for pediatric patients based on weight

Administration

  • Tablets should be taken in the morning, before eating
  • Tablets should not be chewed or crushed, but should be swallowed whole

Interaction

  • Interaction with compound absorption dependent on pH
  • Potential decrease in antifungal plasma levels with co-administration of specific compounds
  • Absorption of atazanavir is pH-dependent, therefore not recommended to be co-administered with PPIs

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Contra-indicated in pregnancy and during breastfeeding

Side effects

  • Well-tolerated in both short-term and long-term studies
  • Potential side effects such as headache, diarrhea, abdominal pain, vomiting, constipation, dry mouth, changes in appetite, muscle pain, drowsiness, and dizziness
  • Rare reports of serious side effects such as blood dyscrasias and hepatic enzyme abnormalities

Pregnancy and lactation

  • US FDA pregnancy category 'C'
  • No adequate and well-controlled studies in pregnant women
  • Potential excretion in human milk, with a decision to be made regarding continued nursing

Precautions and warnings

  • Symptomatic response does not preclude the presence of gastric or oesophageal malignancy
  • Regular surveillance for patients on long-term treatment
  • Potential increase in the risk of hip, wrist, and spine fracture with long-term high-dose use
  • Risk of cross-hypersensitivity reactions with other PPIs or substituted benzimidazoles
  • Potential occurrence of hypomagnesaemia, influence on vitamin B12 absorption, and rare subacute cutaneous lupus erythematosus cases

Use in special populations

  • No dosage adjustment necessary for patients with renal or hepatic impairment
  • Not recommended for use in children due to lack of safety and efficacy data

Overdose effects

  • Maximum established exposure and effects
  • Effects generally minimal, reversible without further medical intervention
  • No specific antidote known, not dialysable, treatment should be symptomatic and general supportive measures should be utilized

Storage conditions

  • Temperature to be kept below 30°C, away from light & moisture, and out of the reach of children

Chemical structure

  • Molecular Formula: C18H21N3O3S
  • Chemical Structure image

Common questions

  • Rabifast 20 mg Tablet use, side effects, dosage, use during pregnancy or breastfeeding, overdose effects, duration of treatment, precautions, and potential bone problems during prolonged use

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