Rabium 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 5.00 (50's pack: ৳ 250.00)

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Cosmic pharma ltd

Title

  • Rabium Gastro-resistant Tablets

Categories

  • Medicine
  • Gastrointestinal

Description

  • Proton pump inhibitor for the treatment of active duodenal ulcer, active benign gastric ulcer, GERD, and Zollinger-Ellison Syndrome, in pediatric and adult patients

Indication

  • Active duodenal ulcer
  • Active benign gastric ulcer
  • Symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Gastro-esophageal Reflux Disease Long-term Management (GERD Maintenance)
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Zollinger-Ellison Syndrome
  • In combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori in patients with peptic ulcer disease

Pharmacology

  • Suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase

Dosage

  • 20 mg once daily for active duodenal ulcer and active benign gastric ulcer
  • 20 mg once daily for 4-8 weeks for erosive or ulcerative GERD
  • 20 mg or 10 mg once daily for long-term management of GERD
  • 10 mg once daily for symptomatic GERD treatment
  • 5 mg or 10 mg once daily for pediatric GERD patients
  • Starting dose of 60 mg once daily for Zollinger-Ellison Syndrome, titrated upwards based on individual needs
  • Combination therapy for H. pylori eradication

Administration

  • To be taken in the morning before eating, should be swallowed whole

Interaction

  • Potential interaction with compounds dependent on pH for absorption
  • Co-administration with ketoconazole or itraconazole may decrease antifungal plasma levels
  • No interaction with liquid antacids observed
  • Atazanavir absorption is pH-dependent, should not be co-administered with PPIs

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Contra-indicated in pregnancy and during breastfeeding

Side effects

  • Well-tolerated, may cause headache, diarrhea, abdominal pain, vomiting, constipation, dry mouth, changes in appetite, muscle pain, drowsiness, dizziness

Pregnancy and lactation

  • US FDA pregnancy category 'C'
  • No adequate and well-controlled studies in pregnant women
  • Likely excreted in human milk, decision should consider risks and benefits to the mother

Precautions and warnings

  • Possibility of gastric or esophageal malignancy should be excluded prior to treatment
  • Regular surveillance for long-term treatment
  • Modestly increase risk of hip, wrist, spine fracture especially in the elderly or with other risk factors
  • Cross-hypersensitivity reactions possible with other PPIs
  • Hepatic enzyme abnormalities and drug related safety problems reported
  • Severe hypomagnesaemia reported after prolonged PPI treatment
  • Reduction in vitamin B12 absorption, risk of subacute cutaneous lupus erythematosus
  • Reduced absorption of vitamin D and interference with laboratory tests

Special populations

  • No dosage adjustment for renal or hepatic impairment
  • Not recommended for use in children

Overdose effects

  • Effects generally minimal and reversible without medical intervention
  • No specific antidote known, not dialysable
  • Treatment should be symptomatic and supportive

Chemical structure

  • Molecular Formula: C18H21N3O3S

Commonly asked questions

  • Description of the tablet
  • Recommended uses
  • Common side effects
  • Dosage and administration guidelines
  • Recommendations for pregnant or breastfeeding individuals
  • Actions in case of overdose
  • Duration of treatment
  • Other considerations and precautions

Storage conditions

  • Keep below 30°C, away from light and moisture
  • Keep out of the reach of children

Therapeutic class

  • Proton Pump Inhibitor

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