Rasonix 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 7.00 (5 x 10: ৳ 350.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Incepta pharmaceuticals ltd
Also available as
Rasonix 20 mg capsule Rasonix jr 10 mg capsule

Title

  • Rasonix 20 mg Gastro-resistant Tablet

Categories

  • Medicine
  • Gastroenterology

Description

  • Rasonix Gastro-resistant tablets for the treatment of active duodenal ulcer, active benign gastric ulcer, symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD), gastro-esophageal reflux disease long-term management (GERD maintenance), symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD), Zollinger-Ellison Syndrome, in combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori in patients with peptic ulcer disease.

Dosage

  • 20 mg to be taken once daily in the morning for active duodenal ulcer and active benign gastric ulcer
  • 20 mg to be taken once daily for four to eight weeks for erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Maintenance dose of rabeprazole sodium 20 mg or 10 mg once daily for long-term management of GERD
  • 10 mg once daily in patients without esophagitis for symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • 5 mg once daily for 12 weeks in pediatric patients 1 to 11 years of age (less than 15 kg)
  • 10 mg once daily for 12 weeks in pediatric patients 1 to 11 years of age (15 kg or more)
  • 60 mg once a day for Zollinger-Ellison Syndrome with possible titration upwards to 120 mg/day
  • Rabeprazole sodium 20 mg twice daily, clarithromycin 500 mg twice daily, and amoxicillin 1g twice daily for 7 days for the eradication of H. pylori

Pharmacology

  • Rabeprazole suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase at the secretory surface of the gastric parietal cell, characterized as a gastric proton-pump inhibitor.

Administration

  • Rabeprazole tablets should be taken in the morning, before eating, and swallowed whole.

Interaction

  • Co-administration with ketoconazole or itraconazole may decrease antifungal plasma levels, while no interaction with liquid antacids was observed. Co-administration with atazanavir is not recommended.

Contraindications

  • Hypersensitivity to the active substance or excipients, and contraindicated in pregnancy and during breastfeeding.

Side effects

  • May cause headache, diarrhea, abdominal pain, vomiting, constipation, dry mouth, increased or decreased appetite, muscle pain, drowsiness, and dizziness.

Pregnancy and lactation

  • US FDA pregnancy category 'C', no adequate and well-controlled studies in pregnant women, likely to be excreted in human milk.

Precautions and warnings

  • Symptomatic response does not preclude the presence of gastric or esophageal malignancy, therefore the possibility of malignancy should be excluded prior to commencing treatment.
  • Patients on long-term treatment should be kept under regular surveillance.
  • Proton pump inhibitors may increase the risk of hip, wrist, and spine fracture, particularly in the elderly or in the presence of other recognised risk factors.
  • A risk of cross-hypersensitivity reactions with other proton pump inhibitor or substituted benzimidazoles cannot be excluded.
  • Hypomagnesemia, interference with vitamin B12 absorption, subacute cutaneous lupus erythematosus (SCLE), and interference with laboratory tests should be considered.

Special populations

  • No dosage adjustment is necessary for patients with renal or hepatic impairment.
  • Not recommended for use in children due to a lack of data on safety and efficacy.

Overdose effects

  • Effects are generally minimal and reversible without further medical intervention. No specific antidote is known.

Therapeutic class

  • Proton Pump Inhibitor

Storage conditions

  • Keep below 30°C temperature, away from light & moisture, and out of the reach of children.

Chemical structure

  • Molecular Formula: C18H21N3O3S

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