Naproben Plus 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 13.00 (3 x 10: ৳ 390.00)
Strip Price: ৳ 130.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Benham pharmaceuticals ltd

Title

  • Naproxen & Esomeprazole Tablet

Categories

  • Pain Relief
  • Gastrointestinal Health

Description

  • Relieves signs & symptoms of Osteoarthritis, Rheumatoid Arthritis, Ankylosing spondylitis
  • Decreases risk of developing gastric ulcers
  • Consists of an immediate release Esomeprazole Magnesium layer & an enteric-coated Naproxen core

Dosage

  • Adult dosage: One tablet twice daily of either: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
  • Adolescent dosage (weight-dependent)

Administration

  • Tablet should be taken at least 30 minutes before meals

Interaction

  • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
  • Concomitant use with warfarin may increase risk of bleeding
  • May interfere with absorption of drugs like Ketoconazole, iron salts and digoxin
  • Administration with high-fat food may affect absorption

Contraindications

  • Known hypersensitivity to any tablet component
  • History of allergic-type reactions after taking aspirin or other NSAIDs
  • Use during peri-operative period in the setting of CABG surgery

Side Effects

  • Decreases occurrence of gastric ulcers and GI adverse events compared to Naproxen alone
  • May be associated with small increased risk of arterial thrombotic events
  • May cause GI disturbances, oedema, hypertension, cardiac failure
  • Less frequently observed adverse events include gastritis, gastrointestinal bleeding, diarrhoea, constipation

Pregnancy & Lactation

  • Should not be used during the third trimester of pregnancy
  • Should not be used during breastfeeding
  • Use may impair female fertility
  • Use during first and second trimester only if potential benefit outweighs potential risk to fetus

Precautions & Warnings

  • Avoid combination with other NSAIDs
  • Minimize dose and duration
  • Use with caution in older people and patients with certain conditions
  • Monitor patients for adverse reactions especially in older people and those with gastrointestinal disease
  • Appropriate monitoring required for patients with history of hypertension, heart failure, and renal impairment

Use in Special Populations

  • Use caution and consider dosage adjustment in elderly patients
  • Not recommended for patients with moderate to severe or severe renal impairment
  • Monitor patients with mild to moderate hepatic impairment
  • Not recommended in patients with severe hepatic impairment

Overdose Effects

  • Symptoms may include lethargy, dizziness, abdominal discomfort, nausea, renal dysfunction
  • No specific antidotes
  • Patients should receive symptomatic and supportive care
  • Forced diuresis, alkalinization of urine or hemoperfusion may not be useful due to high protein binding

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store below 30°C, protect from light & moisture, Keep out of reach of children

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