Esoxen 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 12.50 (3 x 10: ৳ 375.00)
Strip Price: ৳ 125.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Novatek pharmaceuticals ltd
Also available as
Esoxen 375 mg tablet

Indications

  • Osteoarthritis
  • Rheumatoid arthritis
  • Ankylosing spondylitis
  • Decrease the risk of developing gastric ulcers

Pharmacology

  • Immediate release Esomeprazole Magnesium layer
  • Enteric-coated Naproxen core
  • Prostaglandin synthesis inhibition
  • Proton pump inhibitor
  • Suppression of gastric acid secretion

Dosage

  • Use lowest effective dose
  • Adjust dosage based on patient's weight
  • Twice daily dosing

Administration

  • Take at least 30 minutes before meals
  • Do not split, chew, crush, or dissolve the tablet

Interaction

  • Reduced antihypertensive effect with NSAIDs
  • Increased risk of bleeding with warfarin
  • Interference with drug absorption by Esomeprazole
  • Effect of food on absorption

Contraindications

  • Hypersensitivity to any component
  • History of allergic reactions to aspirin or NSAIDs
  • Use during peri-operative period in coronary artery bypass graft surgery

Side Effects

  • Decrease in occurrence of gastric ulcers
  • Gastrointestinal adverse events reduction
  • Increased risk of arterial thrombotic events
  • Oedema, hypertension, and cardiac failure
  • Gastrointestinal adverse events
  • Renal injury
  • Hypertension and heart failure risk
  • Gastrointestinal bleeding risk

Pregnancy & Lactation

  • Contraindicated in third trimester of pregnancy
  • Avoid during breastfeeding
  • Impairment of female fertility

Precautions & Warnings

  • Avoid combination with other NSAIDs
  • Minimize undesirable effects by using lowest effective dose
  • Risk-factors for NSAID related complications
  • Increased frequency of adverse reactions in older people
  • Gastrointestinal, cardiovascular, cerebrovascular, and renal effects
  • Long-term treatment surveillance

Use in Special Populations

  • Caution in elderly patients
  • Not recommended for patients with moderate to severe renal impairment
  • Close monitoring in patients with mild to moderate hepatic impairment

Overdose Effects

  • Symptoms of Naproxen overdose
  • Symptoms of esomeprazole overdose
  • Management of overdose for both components

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Temperature below 30°C
  • Protection from light & moisture
  • Keep out of reach of children

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