Natagen 5% (Ophthalmic Suspension)

5 ml drop: ৳ 100.30

Medicine Details

Category	Details
Generic	Natamycin
Company	General pharmaceuticals ltd

Indications

Treatment of fungal blepharitis
Treatment of conjunctivitis caused by susceptible organisms
Treatment of keratitis caused by susceptible organisms

Pharmacology

Derived from Streptomyces natalensis
Antifungal effects by binding to sterols in the fungal cell membrane
In vitro activity against yeast and filamentous fungi
Primarily fungicidal
Topical administration produces effective concentration within the corneal stroma

Dosage & Administration

Preferred initial dosage: 1 drop instilled in the conjunctival sac at 1-2 hours interval
Frequency of application can be reduced to 1 drop 6-8 times daily after 3-4 days
Therapy usually continued for 14-21 days for fungal keratitis
Pediatric use: Safety and effectiveness not established

Interaction

May increase spread of fungal eye infection when used with topical corticosteroid

Contraindications

Hypersensitivity to any component

Side Effects

Eye irritation
Eye discomfort
Eye edema
Conjunctival chemosis
Hyperemia

Pregnancy & Lactation

Pregnancy category C
Animal reproduction studies not conducted
Unknown effects on fetal harm and reproduction capacity
Caution advised for pregnant and nursing women

Precautions & Warnings

Do not touch dropper tip to any surface
Patient should not wear contact lenses with signs and symptoms of fungal blepharitis, conjunctivitis, and keratitis
Failure to improve keratitis after 7-10 days suggests non-susceptible microorganism
Continuation of therapy based on clinical re-evaluation and additional laboratory studies
Adherence of the suspension to areas of epithelial ulceration or retention in the fornices occurs regularly

Therapeutic Class

Ophthalmic antibacterial drugs

Storage Conditions

Store in a cool and dry place
Protect from light
Do not freeze
Do not use for longer than one month after opening

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