Natagen 5% (Ophthalmic Suspension)

Indications

• Treatment of fungal blepharitis
• Treatment of conjunctivitis caused by susceptible organisms
• Treatment of keratitis caused by susceptible organisms

Pharmacology

• Derived from Streptomyces natalensis
• Antifungal effects by binding to sterols in the fungal cell membrane
• In vitro activity against yeast and filamentous fungi
• Primarily fungicidal
• Topical administration produces effective concentration within the corneal stroma

Dosage & Administration

• Preferred initial dosage: 1 drop instilled in the conjunctival sac at 1-2 hours interval
• Frequency of application can be reduced to 1 drop 6-8 times daily after 3-4 days
• Therapy usually continued for 14-21 days for fungal keratitis
• Pediatric use: Safety and effectiveness not established

Interaction

• May increase spread of fungal eye infection when used with topical corticosteroid

Contraindications

• Hypersensitivity to any component

Side Effects

• Eye irritation
• Eye discomfort
• Eye edema
• Conjunctival chemosis
• Hyperemia

Pregnancy & Lactation

• Pregnancy category C
• Animal reproduction studies not conducted
• Unknown effects on fetal harm and reproduction capacity
• Caution advised for pregnant and nursing women

Precautions & Warnings

• Do not touch dropper tip to any surface
• Patient should not wear contact lenses with signs and symptoms of fungal blepharitis, conjunctivitis, and keratitis
• Failure to improve keratitis after 7-10 days suggests non-susceptible microorganism
• Continuation of therapy based on clinical re-evaluation and additional laboratory studies
• Adherence of the suspension to areas of epithelial ulceration or retention in the fornices occurs regularly

Therapeutic Class

• Ophthalmic antibacterial drugs

Storage Conditions

• Store in a cool and dry place
• Protect from light
• Do not freeze
• Do not use for longer than one month after opening

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