Maxineb 5 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Nebivolol hydrochloride |
| Company | Aristopharma ltd |
| Also available as |
Indications
- Hypertension
- Treatment of essential hypertension
- Chronic heart failure (CHF)
- Treatment of stable mild and moderate chronic heart failure in elderly patients
Pharmacology
- Beta adrenergic receptor blocking agent
- Inhibition of beta1 and beta2 adrenergic receptors
- Lack of intrinsic sympathomimetic and membrane stabilizing activity
- Decreased heart rate
- Decreased myocardial contractility
- Diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers
- Suppression of renin activity
- Vasodilation and decreased peripheral vascular resistance
- Metabolized by glucuronidation and hydroxylation by CYP2D6
- Mean peak plasma concentrations occur approximately 1.5 to 4 hours post-dosing
- In vitro human plasma protein binding of approximately 98%
- Predominantly metabolized via direct glucuronidation
- Concomitant administration with digoxin or warfarin
Dosage & Administration
- Recommended starting dose of 5 mg once daily
- Can be increased at 2-week intervals up to 40 mg
- Absorption similar to an oral solution
- Mean peak plasma concentrations occur approximately 1.5 to 4 hours post-dosing
- Food does not alter the pharmacokinetics
- Administered without regard to meals
Interaction
- Caution with myocardial depressants or inhibitors of AV conduction
- Not to be combined with other beta blockers
- Use caution when co-administered with CYP2D6 inhibitors
Contraindications
- Severe bradycardia
- Heart block greater than first degree
- Cardiogenic shock
- Decompensated cardiac failure
- Sick sinus syndrome
- Severe hepatic impairment
- Hypersensitivity to any component of this product
Side Effects
- Headache
- Nausea
- Bradycardia
Precautions & Warnings
- Abrupt Cessation of Therapy
- Cardiac Failure
- Angina and Acute Myocardial Infarction
- Bronchospastic Diseases
- Anesthesia and Major Surgery
- Diabetes and Hypoglycemia
- Thyrotoxicosis
- Peripheral Vascular Disease
- Non-dihydropyridine Calcium Channel Blockers
Use in Special Populations
- Impaired Renal Function
- Impaired Hepatic Function
- Risk of Anaphylactic Reactions
Therapeutic Class
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children