Cardoneb 2.5 mg (Tablet)

Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Nebivolol hydrochloride
Company Eskayef pharmaceuticals ltd
Also available as
Cardoneb 5 mg tablet

Indications

  • Hypertension
  • Treatment of essential hypertension
  • Chronic heart failure (CHF)
  • Treatment of stable mild and moderate chronic heart failure in elderly patients.

Pharmacology

  • β adrenergic receptor blocking agent
  • Inhibits both β1 and β1 adrenergic receptors
  • Lacks intrinsic sympathomimetic and membrane stabilizing activity
  • Suppression of renin activity
  • Vasodilation and decreased peripheral vascular resistance

Pharmacokinetics

  • Metabolized by glucuronidation and hydroxylation by CYP2D6
  • Effective half-life of about 12 hours in CYP2D6 extensive metabolizers
  • Mean peak plasma nebivolol concentrations occur approximately 1.5 to 4 hours post-dosing

Dosage & Administration

  • Recommended starting dose is 5 mg once daily
  • Dose can be increased up to 40 mg for patients requiring further reduction in blood pressure

Contraindications

  • Severe bradycardia
  • Heart block greater than first degree
  • Cardiogenic shock
  • Decompensated cardiac failure
  • Sick sinus syndrome (unless a permanent pacemaker is in place)
  • Severe hepatic impairment
  • Hypersensitive to any component

Side Effects

  • Headache
  • Nausea
  • Bradycardia

Interaction

  • Use with care when myocardial depressants or inhibitors of AV conduction are used concurrently
  • Should not be combined with other β-blockers
  • Use caution when co-administered with CYP2D6 inhibitors

Precautions & Warnings

  • Patients with coronary artery disease should be advised against abrupt discontinuation of therapy
  • Sympathetic stimulation is vital in congestive heart failure
  • Patients with bronchospastic diseases should not receive β-blockers
  • Use caution during anesthesia and major surgery
  • Patients subject to spontaneous hypoglycemia should be advised about possibilities
  • Use with caution in patients with hyperthyroidism, peripheral vascular disease, and receiving calcium channel blockers

Use in Special Populations

  • Use with caution in patients with severe renal impairment
  • Use with caution in patients with moderate hepatic impairment
  • Patients with a history of severe anaphylactic reactions may be more reactive to repeated challenges

Therapeutic Class

  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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