Nebilol 5 mg (Tablet)

Unit Price: ৳ 8.06 (3 x 14: ৳ 338.52)
Strip Price: ৳ 112.84

Medicine Details

Category Details
Generic Nebivolol hydrochloride
Company Opsonin pharma ltd
Also available as

Indications

  • Hypertension
  • Treatment of essential hypertension
  • Chronic heart failure (CHF)
  • Treatment of stable mild and moderate chronic heart failure in addition to standard therapies in elderly patients

Pharmacology

  • β adrenergic receptor blocking agent
  • Inhibition of both β1 and β1 adrenergic receptors
  • Lack of intrinsic sympathomimetic and membrane stabilizing activity
  • Decreased heart rate
  • Decreased myocardia contractility
  • Diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers
  • Suppression of renin activity
  • Vasodilation and decreased peripheral vascular resistance

Dosage & Administration

  • Individualized dose based on patient's needs
  • Recommended starting dose of 5 mg once daily
  • Dose can be increased at 2-week intervals up to 40 mg
  • Administration with or without food
  • Not beneficial with more frequent dosing regimen

Interaction

  • Careful use with myocardial depressants or inhibitors of AV conduction
  • Avoid combination with other β-blockers
  • Cautious monitoring with catecholamine-depleting drugs
  • Caution when co-administered with CYP2D6 inhibitors

Contraindications

  • Severe bradycardia
  • Heart block greater than first degree
  • Cardiogenic shock
  • Decompensated cardiac failure
  • Sick sinus syndrome (unless a permanent pacemaker is in place)
  • Severe hepatic impairment (Child-Pugh >B)
  • Hypersensitivity to any component of the product

Side Effects

  • Headache
  • Nausea
  • Bradycardia

Precautions & Warnings

  • Advise against abrupt discontinuation in patients with coronary artery disease
  • Caution in patients with compensated congestive heart failure
  • Not studied in patients with angina pectoris or recent MI
  • Patients with bronchospastic diseases should not receive β-blockers
  • Close monitoring needed during anesthesia and major surgery
  • Use with caution in patients with diabetes, thyrotoxicosis, peripheral vascular disease, or impaired renal/hepatic function
  • Potential increased reactivity to allergens for patients with severe anaphylactic reactions

Use in Special Populations

  • Caution in patients with severe renal impairment
  • Not studied in patients receiving dialysis
  • Caution in patients with moderate hepatic impairment
  • Contraindicated in patients with severe hepatic impairment
  • Increased reactivity to repeated challenges for patients with a history of severe anaphylactic reactions to allergens

Therapeutic Class

  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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