Vasocor 5 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Nebivolol hydrochloride |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Hypertension
- Treatment of essential hypertension
- Chronic heart failure (CHF)
- Treatment of stable mild and moderate chronic heart failure in elderly patients.
Pharmacology
- β adrenergic receptor blocking agent
- Inhibition of β1 and β1 adrenergic receptors
- Lack of intrinsic sympathomimetic and membrane stabilizing activity
- Decreased heart rate
- Decreased myocardial contractility
- Diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers
- Suppression of renin activity
- Vasodilation and decreased peripheral vascular resistance
- Metabolism by glucuronidation and hydroxylation by CYP2D6
- Mean peak plasma concentration
- Plasma protein binding
- Excretion in urine and feces
- Interaction with digoxin and warfarin
Dosage & Administration
- Individualized dose based on patient needs
- Recommended starting dose of 5 mg once daily
- Can be administered with or without food
- Dose increment at 2-week intervals up to 40 mg
- Unlikely benefit from more frequent dosing regimen
Interaction
- Caution with myocardial depressants or AV conduction inhibitors
- Avoid combination with other β-blockers
- Monitor patients receiving catecholamine-depleting drugs
- Use caution with CYP2D6 inhibitors (quinidine, propafenone, fluoxetine, paroxetine, etc.)
Contraindications
- Severe bradycardia
- Greater than first-degree heart block
- Cardiogenic shock
- Decompensated cardiac failure
- Sick sinus syndrome without a permanent pacemaker
- Severe hepatic impairment
- Hypersensitivity to any component of the product
Side Effects
- Headache
- Nausea
- Bradycardia
Precautions & Warnings
- Abrupt cessation of therapy
- Cardiac failure precautions
- Angina and acute myocardial infarction considerations
- Avoidance in bronchospastic diseases
- Anesthesia and major surgery monitoring
- Diabetes and hypoglycemia precautions
- Thyrotoxicosis implications
- Peripheral vascular disease caution
- Caution with non-dihydropyridine calcium channel blockers
Use in Special Populations
- Caution in patients with impaired renal function
- Caution in patients with moderate hepatic impairment
- Contraindicated in patients with severe hepatic impairment
- Risk of anaphylactic reactions in patients with a history of severe reactions to allergens
Therapeutic Class
Beta-adrenoceptor blocking drugs, Beta-blockers
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.