Vasocor 2.5 mg (Tablet)

Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Nebivolol hydrochloride
Company Popular pharmaceuticals ltd
Also available as
Vasocor 5 mg tablet

Indications

  • Hypertension
  • Treatment of essential hypertension
  • Chronic heart failure (CHF)
  • Treatment of stable mild and moderate chronic heart failure in elderly patients.

Pharmacology

  • β adrenergic receptor blocking agent
  • Inhibits both β1 and β1 adrenergic receptors
  • Lacks intrinsic sympathomimetic and membrane stabilizing activity
  • Decreased heart rate
  • Decreased myocardia contractility
  • Diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers
  • Suppression of renin activity
  • Vasodilation and decreased peripheral vascular resistance
  • Metabolized by glucuronidation and hydroxylation by CYP2D6
  • Mean peak plasma nebivolol concentrations occur approximately 1.5 to 4 hours post-dosing
  • 98% human plasma protein binding to albumin
  • Predominantly metabolized via direct glucuronidation of parent
  • 38% of the dose recovered in urine and 44% in feces for EMs and 67% in urine and 13% in feces for PMs

Dosage & Administration

  • Recommended starting dose is 5 mg once daily for most patients
  • Dose can be increased at 2-week intervals up to 40 mg
  • More frequent dosing regimen is unlikely to be beneficial

Interaction

  • Use with care when myocardial depressants or inhibitors of AV conduction are used concurrently
  • Contraindicated with other β-blockers
  • Use caution when co-administered with CYP2D6 inhibitors (quinidine, propafenone, fluoxetine, paroxetine, etc.)

Contraindications

  • Severe bradycardia
  • Heart block greater than first degree
  • Cardiogenic shock
  • Decompensated cardiac failure
  • Sick sinus syndrome (unless a permanent pacemaker is in place)
  • Severe hepatic impairment (Child-Pugh >B)
  • Hypersensitivity to any component of this product

Side Effects

  • Headache
  • Nausea
  • Bradycardia

Precautions & Warnings

  • Abrupt Cessation of Therapy
  • Cardiac Failure
  • Angina and Acute Myocardial Infarction
  • Bronchospastic Diseases
  • Anesthesia and Major Surgery
  • Diabetes and Hypoglycemia
  • Thyrotoxicosis
  • Peripheral Vascular Disease
  • Non-dihydropyridine Calcium Channel Blockers

Use in Special Populations

  • Impaired Renal Function
  • Impaired Hepatic Function
  • Risk of Anaphylactic Reactions

Therapeutic Class

  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

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