Nebita 5 mg (Tablet)

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00

Medicine Details

Indications

  • Hypertension
  • Treatment of essential hypertension
  • Chronic heart failure (CHF)
  • Treatment of stable mild and moderate chronic heart failure in elderly patients.

Pharmacology

  • β adrenergic receptor blocking agent
  • β1 and β1 adrenergic receptors inhibition
  • lacks intrinsic sympathomimetic and membrane stabilizing activity
  • decreased heart rate
  • decreased myocardia contractility
  • diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers
  • suppression of renin activity
  • vasodilation and decreased peripheral vascular resistance
  • metabolized by glucuronidation and hydroxylation by CYP2D6
  • plasma protein binding of approximately 98%
  • absorption similar to an oral solution
  • metabolized via direct glucuronidation, N-dealkylation and oxidation via cytochrome P450 2D6
  • no significant interaction with digoxin
  • no significant effects on the anticoagulant activity of warfarin
  • starting dose reduction in patients with moderate hepatic impairment

Dosage & Administration

  • Recommended starting dose of 5 mg once daily
  • can be increased at 2-week intervals up to 40 mg
  • administered with or without food
  • individualized to the needs of the patient
  • more frequent dosing regimen unlikely to be beneficial

Interaction

  • Careful use with myocardial depressants or inhibitors of AV conduction
  • Avoid combining with other β-blockers
  • Use caution when co-administered with CYP2D6 inhibitors

Contraindications

  • Severe bradycardia
  • Heart block greater than first degree
  • Cardiogenic shock
  • Decompensated cardiac failure
  • Sick sinus syndrome (unless a permanent pacemaker is in place)
  • Severe hepatic impairment
  • Hypersensitivity to any component of this product

Side Effects

  • Headache
  • Nausea
  • Bradycardia

Precautions & Warnings

  • Advised against abrupt discontinuation of therapy
  • Caution in patients with compensated congestive heart failure
  • Not studied in patients with angina pectoris or recent MI
  • Patients with bronchospastic diseases should not receive β-blockers
  • Closely monitored perioperatively
  • May mask some manifestations of hypoglycemia
  • May mask clinical signs of hyperthyroidism
  • May precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease
  • Caution in patients treated concomitantly with non-dihydropyridine calcium channel blockers
  • Used with caution in patients with severe renal impairment
  • Used with caution in patients with moderate hepatic impairment
  • More reactive to repeated challenges of allergens
  • Unresponsive to usual doses of epinephrine used to treat allergic reactions

Use in Special Populations

  • Used with caution in patients with severe renal impairment
  • Not studied in patients receiving dialysis
  • Used with caution in patients with moderate hepatic impairment
  • Contradicted in patients with severe hepatic impairment
  • Patients with a history of severe anaphylactic reactions may be more reactive to repeated challenges

Therapeutic Class

  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

Related Brands