Loramide 2 mg (Capsule)

Title

• Loramide

Categories

• Medicine
• Pharmacology
• Therapeutic Class

Description

• Loramide is indicated for acute and chronic diarrhea, abdominal cramps associated with diarrhea, Crohn's disease, postgastric surgery, and ulcerative colitis. It inhibits peristaltic activity in the intestines and increases the tone of the anal sphincter. Dosage varies for adults and children based on the severity of the condition. It is contraindicated in cases of hypersensitivity to the drug and in patients who must avoid constipation. Precaution must be taken when used in cases of severe hepatic disturbance. Overdose may result in constipation, CNS depression, and nausea. Storage should be in a cool and dry place protected from light.

Dimensions

• Capsules

Color options

None

Functions

• Inhibits peristaltic activity in the intestines
• Increases tone of the anal sphincter

Materials

Not applicable

Technical specifications

• Absorption: More than 65%
• Peak serum levels: 2-3µgm/litre at about 4 hours
• Route of elimination: 0.63-1.4% in urine, 58% in the bile, 15-23% in the faeces
• Orally administered

Design elements

None

Usability features

• Indicated for adult and pediatric use
• Dosage varies based on severity
• Contraindicated in specific conditions
• Caution in cases of severe hepatic disturbance

Indication

• Acute diarrhea
• Chronic diarrhea
• Abdominal cramps associated with diarrhea
• Crohn's disease
• Postgastric surgery
• Ulcerative colitis

Pharmacology

• Inhibition of peristaltic activity
• Increased intestinal transit time
• Binding to opiate receptor in the gut wall
• Reduction of propulsive peristalsis
• Increased anal sphincter tone
• Presystemic first-pass metabolism
• Little to no action centrally

Dosage administration

• Adults: 2 capsules initially followed by 1 capsule after every loose stool
• Usual dosage: 3-4 capsules/day, maximum 8 capsules/day
• Children (9-12 years): 1 capsule after each loose stool, maximum 6 capsules/day
• Children (5-9 years): 1 capsule 4 times daily, maximum 4 capsules/day
• Chronic diarrhea: Adults 2-4 capsules daily in divided doses, Children 1-2 capsules daily

Interaction

• No available data

Contraindications

• Hypersensitivity to the drug
• Patients who must avoid constipation
• Not to be used alone in acute dysentery characterized by blood in the stool and elevated body temperature

Side effects

• Abdominal pain
• Dry mouth
• Dizziness
• Fatigue
• Skin rashes

Pregnancy lactation

• Safety in human pregnancy not established
• Caution advised during nursing if administered to nursing mother

Precautions warnings

• Use with caution in severe hepatic disturbance

Overdose effects

• Constipation
• CNS depression
• Nausea

Storage conditions

• Store in a cool, dry place protected from light
• Keep out of reach of children

Therapeutic class

• Anti-diarrhoeal
• Anti-motility drugs

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