Nicor 10 mg (Tablet)
Unit Price: ৳ 3.00 (5 x 10: ৳ 150.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Nicorandil |
| Company | Orion pharma ltd |
Indications
- Prevention of angina pectoris
- Long-term treatment of angina pectoris
Pharmacology
- Arteriole dilation
- Coronary artery dilation
- Potassium channel opening
- Guanylate cyclase stimulation
- Venous vasodilatation
- Preload reduction
- Afterload reduction
- Improved coronary blood flow
Dosage & Administration
- Usual therapeutic range of 10 to 20 mg twice daily
- Starting dose of 10 mg twice daily
- Dose titration according to patient's needs and response
- Elderly patients dosage considerations
- Dose reduction for hepatic impairment
- Not recommended for children
Interaction
- Possible potentiation of effect with other vasodilators
- Interaction with beta-blockers
- Interaction with calcium antagonists
- Interaction with digoxin
- Interaction with rifampicin
- Interaction with cimetidine
- Potential interaction with tricyclic antidepressants
- Potential interaction with antihypertensive drugs
- Potentiation effect possibility with alcohol
Contraindications
- Hypersensitivity to Nicorandil
- Cardiogenic shock
- Acute myocardial infarction with acute left ventricular failure and low filling pressures
- Hypotension
- Use with phosphodiesterase-5 inhibitors
- Caution in patients with blood volume depletion
- Caution in patients with low systolic blood pressure
- Caution in patients with mouth ulceration or stomatitis
- Caution in patients with glaucoma
- Caution in hypertensive patients using antihypertensive drugs
- Avoid use in cardiogenic shock and acute myocardial infarction with acute left ventricular failure and low filling pressures
Side Effects
- Headache
- Flushing
- Dizziness
- Nausea
- Vomiting
- Weakness
- Hypotension
- Reflex tachycardia
Pregnancy & Lactation
- Caution in pregnant women
- Caution in nursing mothers
Precautions & Warnings
- Hypovolaemia
- Low systolic blood pressure
- Acute pulmonary edema
- Potential impairment of ability to drive or operate machinery
Overdose Effects
- Peripheral vasodilation
- Fall in blood pressure
- Reflex tachycardia
- Monitoring of cardiac function
- General supportive measures
- Plasma volume increase by fluid substitution
- Consideration of vasopressors in life-threatening situations
Therapeutic Class
- Potassium-channel activator
Storage Conditions
- Cool and dry storage
- Protection from light