Rantoin 100 mg (Tablet)

Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Nitrofurantoin
Company Drug international ltd

Indications

  • Treatment of urinary tract infections
  • Prophylaxis of urinary tract infections
  • Effective against Escherichia coli
  • Effective against Enterococci
  • Effective against Staphylococcus aureus
  • Effective against Staphylococcus saprophyticus
  • Effective against Klebsiella species

Pharmacology

  • Antibacterial agent for urinary tract infections
  • Highly soluble in urine
  • Imparts a brown color to urine
  • Inactivates or alters bacterial ribosomal proteins
  • Active against Gram-Positive Aerobes
  • Active against Gram-Negative Aerobes

Dosage

  • Adult tablet dosage: 50-100 mg four times a day
  • Recommended lower dosage for uncomplicated UTIs
  • Therapy duration: one week or 3 days after sterile urine
  • Long-term suppressive therapy dosage: 50-100 mg at bedtime
  • Adult capsule dosage for acute UTIs: 50 mg four times daily for 7 days
  • Long-term suppression capsule dosage: 50-100 mg once a day
  • Prophylaxis capsule dosage: 50 mg four times daily for procedure and 3 days after
  • Nitrofurantoin SR capsule dosage for adults and children over 12 years: One 100 mg capsule every 12 hours for seven days
  • Genito-urinary surgical prophylaxis dosage: One capsule twice daily for 3 days
  • Nitrofurantoin suspension dosage for children: 5-7 mg/kg/day in four divided doses
  • Specific dosage instructions for pediatric patients based on weight

Administration

  • To be taken with food

Interaction

  • Antacids containing Magnesium Trisilicate reduce absorption rate of Nitrofurantoin
  • Uricosuric drugs like Probenecid and Sulfinpyrazone can inhibit renal tubular secretion of Nitrofurantoin

Contraindications

  • Anuria, oliguria or significant impairment of renal function
  • Pregnant patients at 38-42 weeks, during labor and delivery
  • Known hypersensitivity to Nitrofurantoin

Side Effects

  • Nausea
  • Headache
  • Flatulence
  • Diarrhea
  • Dyspepsia
  • Abdominal pain
  • Constipation
  • Emesis
  • Dizziness
  • Drowsiness

Pregnancy & Lactation

  • Pregnancy Category B
  • No adequate and well-controlled studies in pregnant women
  • Drug detection in human breast milk
  • Consideration for nursing infants under one month of age

Precautions & Warnings

  • Discontinue in case of pulmonary reactions
  • Avoid antacid preparations containing magnesium trisilicate while taking Nitrofurantoin

Overdose Effects

  • Occasional incidents of acute overdosage without specific symptoms
  • Induction of emesis recommended

Therapeutic Class

  • Systemic Urinary Anti-infective

Storage Conditions

  • Do not store above 30°C
  • Keep away from light
  • Keep out of the reach of children

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