Norline 2 mg/2 ml (IV Infusion)
2 ml ampoule: ৳ 250.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Norepinephrine bitartrate |
| Company | Radiant pharmaceuticals ltd |
Indications
- Blood pressure control
- Acute hypotensive states
- Pheochromocytomectomy
- Myocardial infarction
- Septicemia
- Drug reactions
- Cardiac arrest
- Hypotension
Pharmacology
- Direct-acting sympathomimetic
- Stimulates beta1- and alpha-adrenergic receptors
- Vasoconstriction
- Reflex slowing of heart rate
Dosage & Administration
- Infusion into large vein
- Blood volume depletion correction
- Diluent: 5 percent dextrose injection
- Average dosage
- High dosage
- Fluid intake
- Duration of therapy
- Adjunctive treatment in cardiac arrest
Interaction
- Contradicted with cyclopropane and halothane anesthesia
- Contraindicated with monoamine oxidase inhibitors
- Caution with antidepressants
- Risk of producing ventricular tachycardia or fibrillation
Contraindications
- Hypotension from blood volume deficits
- Blood volume replacement therapy necessity
- Peripheral and visceral vasoconstriction
- Decreased renal perfusion
- Poor systemic blood flow despite 'normal' BP
- Tissue hypoxia
- Lactate acidosis
- Mesenteric or peripheral vascular thrombosis
Side Effects
- Ischemic injury
- Bradycardia
- Arrhythmias
- Anxiety
- Transient headache
- Respiratory difficulty
- Extravasation necrosis at injection site
- Plasma volume depletion
- Gangrene of extremities
- Hypertension with violent symptoms
Pregnancy & Lactation
- Pregnancy Category C
- Unknown effect on fetal harm
- Caution for nursing women
Precautions & Warnings
- Avoid hypertension
- Site of infusion consideration
- Extravasation prevention
- Antidote for extravasation ischemia
- Monitoring blood pressure
- Avoiding unintentional overdosage
- Avoiding leg vein infusion in elderly patients
Use in Special Populations
- Safety and effectiveness in pediatric patients not established
- Dose selection caution for geriatric patients
- Carcinogenesis, Mutagenesis, Impairment of Fertility - studies not performed
Overdose Effects
- Headache
- Severe hypertension
- Reflex bradycardia
- Marked increase in peripheral resistance
- Decreased cardiac output
Therapeutic Class
- Alpha and Beta-adrenergic agonist
Reconstitution
- Intravenous reconstitution with 5% glucose injection
- Dilution with or without sodium chloride
Storage Conditions
- Store temperature not exceeding 30°C
- Dry place
- Protect from light