Presulock 20 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Olmesartan medoxomil |
| Company | Aristopharma ltd |
Therapeutic Class
- Angiotensin-ll receptor blocker
Indications
- Treatment of hypertension
- May be used alone or in combination with other antihypertensive agents
Pharmacology
- Angiotensin II formation from angiotensin I
- Vasoconstriction
- Stimulation of aldosterone synthesis and release
- Cardiac stimulation
- Renal reabsorption of sodium
- Blocks vasoconstrictor effects of angiotensin II
- Selective binding blockage of angiotensin II to AT 1 receptor
- AT 2 receptor effects
- Renin secretion regulation
Dosage & Administration
- Individualized dosage
- Usual starting dose of 20 mg once daily
- 40 mg dose for further blood pressure reduction
- No advantages of twice-daily dosing
- No initial dosage adjustment for elderly patients
- Consideration for lower starting dose in patients with possible intravascular volume depletion
- May be administered with or without food
- No established safety and effectiveness in pediatric patients
Interaction
- No significant drug interactions reported with digoxin or warfarin
- Bioavailability not significantly altered by antacids
- Not metabolized by cytochrome P450 system
- No effects on P450 enzymes
- Potential deterioration of renal function when co-administered with NSAIDs
- Attenuation of antihypertensive effect by NSAIDs
Contraindications
- Hypersensitivity to any component of the product
Side Effects
- Well-tolerated treatment with incidence of adverse reactions similar to placebo
- Frequency of adverse reactions not dose-related
- Adverse reactions analysis by gender, age, and race groups
- Rate of withdrawals due to adverse reactions
- Common adverse reactions
Pregnancy & Lactation
- Discontinuation of product when pregnancy is detected
- Potential injury to developing fetus
- Uncertain excretion in human milk
- Potential adverse effects on nursing infant
Precautions & Warnings
- Changes in renal function anticipated
- Association with oliguria, progressive azotemia, acute renal failure, and rare cases of death
Overdose Effects
- No experience of overdose reported
- Likely effects including hypotension and tachycardia
- Clinical management of hypotension overdosage
Storage Conditions
- Cool & dry storage below 30°C
- Protection from light & moisture
- Keep out of reach of children
Chemical Structure
- Molecular Formula: C29H30N6O6
Common Questions about Presulock 20 mg Tablet
- Uses of Presulock 20 mg Tablet
- Time to reach peak effect
- Frequency of use
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