Olmevas 20 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Olmesartan medoxomil |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of hypertension
- Can be used alone or in combination with other antihypertensive agents
Pharmacology
- Blocks vasoconstrictor effects of angiotensin II
- Selective binding to AT 1 receptor in vascular smooth muscle
- Higher affinity for AT 1 receptor than for AT 2 receptor
- Does not inhibit ACE (kininase II)
- Does not affect the response to bradykinin
- Inhibits the negative regulatory feedback of angiotensin II on renin secretion
Dosage & Administration
- Recommended starting dose: 20 mg once daily
- May increase to 40 mg for further reduction in blood pressure
- No additional benefit in twice-daily dosing
- No initial dosage adjustment recommended for elderly patients or those with moderate to marked renal/hepatic dysfunction
- Consider lower starting dose for patients with possible depletion of intravascular volume
- May be administered with or without food
- Safety and effectiveness in pediatric patients not established
Interaction
- No significant drug interactions reported with digoxin or warfarin
- Bioavailability not significantly altered by antacids
- Not metabolized by cytochrome P450 system
- No effect on P450 enzymes
- Potential deterioration of renal function with NSAIDs or selective COX-2 inhibitors
- Attenuation of antihypertensive effect by NSAIDs
Contraindications
- Hypersensitivity to any component of the product
Side Effects
- Well-tolerated with incidence of adverse reactions similar to placebo
- Overall frequency of adverse reactions not dose-related
- Withdrawal rate due to adverse reactions: 2.4%
- Dizziness as the most common adverse reaction
- Other adverse reactions include back pain, bronchitis, diarrhea, headache, hyperglycemia, rhinitis, etc.
Pregnancy & Lactation
- Discontinue product when pregnancy is detected
- Can cause injury and death to developing fetus during second and third trimesters
- Potential secretion in low concentration in the milk of lactating rats
- Adverse effects on nursing infant possible
Precautions & Warnings
- Inhibiting the renin-angiotensin-aldosterone system may lead to changes in renal function
- Oliguria, progressive azotemia, acute renal failure, and death reported
- Similar results anticipated in patients treated with Olmevas
Overdose Effects
- No reported experience of overdose
- Likely effects: hypotension, tachycardia, bradycardia
- Management: active support of cardiovascular system, close monitoring, elevation of extremities, attention to circulating fluid volume and urine output
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Store in cool & dry place below 30°C
- Protect from light & moisture
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C29H30N6O6
- Chemical Structure: See image at provided link
Common Questions about Olmevas 20 mg Tablet
- Uses include treatment of high blood pressure
- Average time to reach peak effect: 1 day to 1 week
- Frequency of usage: once or twice a day
- Oral consumption recommended
- Storage: at room temperature, away from heat and direct light
Quick Tips
- Take at the same time every day
- May cause dizziness initially
- Regular tests for urea, creatinine, and potassium levels
- Avoid anti-inflammatory medicines without consulting
- May increase potassium in the blood
- Avoid in pregnancy or breastfeeding
- Do not stop suddenly without doctor's advice