Tenizide 20 mg+12.5 mg (Tablet)

Unit Price: ৳ 8.00 (4 x 7: ৳ 224.00)
Strip Price: ৳ 56.00

Medicine Details

Category Details
Generic Olmesartan medoxomil hydrochlorothiazide
Company Unimed unihealth pharmaceuticals ltd

Indications

  • Treatment of hypertension

Pharmacology

  • Angiotensin-II blocking
  • Aldosterone secretion inhibition
  • Vasoconstrictor blocking
  • Renal tubular electrolyte reabsorption interference
  • Plasma volume reduction
  • Plasma renin activity increase
  • Aldosterone secretion increase
  • Urinary potassium loss
  • Serum potassium decrease
  • Angiotensin-II receptor antagonist
  • Thiazide diuretic action

Dosage & Administration

  • Usual starting dose of 20/12.5 mg
  • Individualized dosing
  • Titration at intervals of 2-4 weeks
  • Maximum dose of two tablets 40/25 mg once daily

Interaction

  • No significant drug interactions with Olmesartan Medoxomil
  • Interaction with Thiazide diuretics by alcohol, barbiturates, narcotics, antidiabetic drugs, other antihypertensive drugs, corticosteroids, ACTH, lithium

Contraindications

  • Hypersensitivity to any component of the product
  • Anuria
  • Hypersensitivity to other sulfonamide-derived drugs

Side Effects

  • Nausea
  • Headache
  • Dizziness
  • Hyperuricemia
  • Upper respiratory tract infection
  • Urinary tract infection
  • Chest pain
  • Back pain
  • Peripheral edema
  • Abdominal pain
  • Dyspepsia
  • Gastroenteritis
  • Diarrhea

Pregnancy & Lactation

  • Safety and effectiveness not established in nursing mother & pregnancy
  • Discontinuation during pregnancy and lactation

Precautions & Warnings

  • Periodic determination of serum electrolytes
  • Detection of electrolyte imbalance
  • Hyperuricemia monitoring
  • Impaired renal function monitoring

Use in Special Populations

  • Usual therapy regimen if creatinine clearance is >30 ml/min
  • Loop diuretics preferred in more severe renal impairment
  • Not recommended in severe renal impairment
  • No dosage adjustment necessary with hepatic impairment
  • Safety and effectiveness not established in pediatric patients
  • Dose selection caution in geriatric patients

Overdose Effects

  • Olmesartan: Manifestations of hypotension and tachycardia
  • Hydrochlorothiazide: Signs of electrolyte depletion, especially hypokalemia and dehydration
  • Accentuated cardiac arrhythmias if digitalis administered with hypokalemia

Therapeutic Class

  • Combined antihypertensive preparations

Storage Conditions

  • Store in cool and dry place
  • Protect from light and moisture
  • Keep out of reach of children

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