Omecent 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Omeprazole
Company Centeon pharma ltd
Also available as

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of the antisecretory effect occurs within one hour
  • Maximum effect occurs within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days after discontinuation

Dosage

  • Dosage for benign gastric and duodenal ulcer
  • Dosage for NSAID-associated duodenal or gastric ulcer
  • Dosage for gastro-esophageal reflux disease
  • Long-term management dosage of acid reflux disease
  • Dosage for acid-related dyspepsia
  • Dosage for prophylaxis of acid aspiration
  • Dosage for Zollinger-Ellison syndrome
  • Dose for Helicobacter pylori eradication regimen
  • Paediatric use in severe ulcerating reflux esophagitis

Administration

  • Direction for use of IV Injection
  • Direction for use of IV Infusion
  • Intravenous administration only
  • IV injection should be given slowly
  • IV infusion should be given over a period of 20-30 minutes or more
  • Reconstituted solution should not be mixed or co-administered with any other drug
  • Freshly prepared solution should be used within a specific timeframe

Interaction

  • Decreased intragastric acidity affecting the absorption of other drugs
  • Metabolism through cytochrome P450 delaying the elimination of other drugs
  • Recommendation to monitor patients receiving warfarin or phenytoin
  • Plasma concentrations of Omeprazole and clarithromycin increased during concomitant administration
  • No evidence of interaction with specific drugs (phenacetin, theophylline, caffeine, etc.)
  • Simultaneous treatment with digoxin leads to a 10% increase in the bioavailability of digoxin

Contraindications

  • Contraindicated in patients with known hypersensitivity to omeprazole
  • Exclusion of malignancy in suspected cases of gastric ulcer before treatment initiation

Side Effects

  • Well tolerated with generally mild and reversible adverse reactions
  • Reported skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme reported in isolated cases
  • Diarrhea and headache reported
  • Gastrointestinal reactions like constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dizziness, light-headedness, and feeling faint associated with treatment
  • Reversible mental confusion, agitation, depression, and hallucinations reported predominantly in severely ill patients
  • Arthritic and myalgic symptoms reported

Pregnancy & Lactation

  • No adverse effects on pregnancy or the health of the fetus/newborn child in prospective epidemiological studies
  • Omeprazole can be used during pregnancy
  • No information available on the passage of Omeprazole into breast milk or its effects on the neonate
  • Discontinuation of breastfeeding if the use of Omeprazole is considered essential
  • Safety and effectiveness not established in pediatric patients less than 18 years of age

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and omeprazole
  • Observational studies suggest increased risk for osteoporosis-related fractures with PPI therapy
  • Atrophic gastritis noted occasionally in gastric corpus biopsies from long-term treated patients
  • Concomitant use with methotrexate may lead to methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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