Omecap 40 mg/vial (IV Injection)

40 mg vial: ৳ 90.00

Medicine Details

Category Details
Generic Omeprazole
Company Chemist laboratories ltd
Also available as
Omecap 20 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 40 mg daily for severe or recurrent cases
  • 10-20 mg daily for prevention of relapse in duodenal ulcer
  • 20 mg once daily for NSAID-associated duodenal or gastric ulcer
  • 20 mg once daily for gastro-esophageal reflux disease
  • 40 mg once daily for 8 weeks in refractory cases
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for acid-related dyspepsia
  • 40 mg on the preceding evening for prophylaxis of acid aspiration
  • 60 mg once daily initially for Zollinger-Ellison syndrome
  • 20 mg twice daily for Helicobacter pylori eradication regimen
  • 10-40 mg daily for pediatric use in severe ulcerating reflux esophagitis
  • 40 mg intravenous injection for prophylaxis of acid aspiration
  • 40 mg intravenous injection for duodenal ulcer, gastric ulcer or reflux esophagitis
  • 60 mg intravenously for Zollinger-Ellison syndrome

Administration

  • Intravenous administration only
  • Slow intravenous injection
  • Intravenous infusion over 20-30 minutes
  • Solution should be used within 4-12 hours of reconstitution

Interaction

  • Reduced absorption of ketoconazole during treatment
  • Metabolized through cytochrome P450 in the liver
  • Potential delay in elimination of diazepam, phenytoin, and warfarin
  • Monitoring recommended for patients receiving warfarin or phenytoin
  • Increased plasma concentrations during concomitant administration with certain drugs

Contraindications

  • Known hypersensitivity
  • When gastric ulcer is suspected without excluding the possibility of malignancy

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, erythema multiforme, and alopecia
  • Diarrhea and headache
  • Constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dry mouth, stomatitis, and candidiasis
  • Dizziness, light headedness, and feeling faint
  • Somnolence, insomnia, and vertigo
  • Reversible mental confusion, agitation, depression, and hallucinations

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child based on studies
  • Use during pregnancy possible
  • No information available on passage into breast milk or effects on neonate
  • Discontinuation of breastfeeding if essential

Precautions & Warnings

  • Avoid concomitant use of clopidogrel
  • Possible association with increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in long-term treatment
  • Potential methotrexate toxicities with concomitant use of PPIs

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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