Gastril 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)

Strip Price: ৳ 50.00

Medicine Details

Category	Details
Generic	Omeprazole
Company	Ethical drugs limited
Also available as	Gastril 40 mg injection

Indications

Gastric and duodenal ulcer
NSAID-associated duodenal and gastric ulcer
Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
Gastro-esophageal reflux disease
Long-term management of acid reflux disease
Acid-related dyspepsia
Severe ulcerating reflux esophagitis
Prophylaxis of acid aspiration during general anesthesia
Zollinger-Ellison syndrome
Helicobacter pylori-induced peptic ulcer

Pharmacology

Inhibitor of gastric acid secretion; blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system

Dosage

20 mg once daily for benign gastric and duodenal ulcer
20 mg once daily for NSAID-associated duodenal or gastric ulcer
20 mg once daily for gastro-esophageal reflux disease
10-20 mg daily for long-term management of acid reflux disease
10-20 mg once daily for acid-related dyspepsia
40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
Initially 60 mg once daily for Zollinger-Ellison syndrome
Omeprazole is recommended at a dose of 20 mg twice daily in association with antimicrobial agents for Helicobacter pylori eradication regimen in peptic ulcer disease
Pediatric use: 10-20 mg once daily for 4-12 weeks (body-weight 10-20 kg), 20-40 mg once daily for 4-12 weeks (body-weight over 20 kg)
IV Injection: 40 mg for prophylaxis of acid aspiration, duodenal ulcer, gastric ulcer, reflux oesophagitis, and Zollinger-Ellison syndrome

Administration

Must be given as a slow intravenous injection or intravenous infusion; reconstituted solution should be used within specified timeframes

Interaction

Decreased intragastric acidity may reduce absorption of ketoconazole
Metabolized in the liver through cytochrome P450, may delay the elimination of diazepam, phenytoin and warfarin
Plasma concentrations of Gastril and clarithromycin are increased during concomitant administration, useful during H. pylori eradication
No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxicillin or antacids

Contraindications

Known hypersensitivity to omeprazole; suspected gastric ulcer which may be malignant

Side Effects

Skin rash, urticaria, and pruritus
Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia
Diarrhea, headache, constipation, nausea/vomiting, flatulence, abdominal pain
Dizziness, light headedness, feeling faint
Paraesthesia, somnolence, insomnia, vertigo
Reversible mental confusion, agitation, depression, hallucinations
Arthritic and myalgic symptoms
Blurred vision, taste disturbance, peripheral edema, increased sweating
Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock
Malaise, fever, bronchospasm, encephalopathy, hepatitis, interstitial nephritis, hepatic failure
Increases in liver enzymes

Pregnancy & Lactation

No adverse effects of omeprazole on pregnancy or on the health of the fetus/newborn child; use during pregnancy is possible; breastfeeding should be discontinued if essential

Precautions & Warnings

Avoid concomitant use with clopidogrel as it may reduce the pharmacological activity of clopidogrel
Observational studies suggest that PPI therapy may be associated with an increased risk for osteoporosis-related fractures
Atrophic gastritis has been noted occasionally in patients treated long-term with Gastril
Concomitant use with methotrexate may lead to methotrexate toxicities