Gastril 40 mg/vial (IV Injection)

40 mg vial: ৳ 70.00

Medicine Details

Category Details
Generic Omeprazole
Company Ethical drugs limited
Also available as
Gastril 20 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days after discontinuation

Dosage

  • For benign gastric and duodenal ulcer
  • For NSAID-associated duodenal or gastric ulcer
  • For gastro-esophageal reflux disease
  • For long-term management of acid reflux disease
  • For acid-related dyspepsia
  • For prophylaxis of acid aspiration
  • For Zollinger-Ellison syndrome
  • For Helicobacter pylori eradication regimen in peptic ulcer disease
  • Pediatric use in severe ulcerating reflux esophagitis
  • IV injection for prophylaxis of acid aspiration
  • IV injection for duodenal ulcer, gastric ulcer or reflux esophagitis
  • IV injection for Zollinger-Ellison syndrome (ZES)

Administration

  • IV Injection direction for use
  • IV Infusion direction for use

Interaction

  • Effect on the absorption of ketoconazole
  • Metabolism in the liver through cytochrome P450
  • Impact on the elimination of diazepam, phenytoin, and warfarin
  • Monitoring of patients receiving warfarin or phenytoin
  • No change in blood concentration of phenytoin in patients on continuous treatment with phenytoin during concomitant treatment
  • No change in coagulation time in patients on continuous treatment with warfarin during concomitant treatment
  • Plasma concentrations of Gastril and clarithromycin during concomitant administration
  • Absence of interaction with various drugs and food
  • Increased bioavailability of digoxin during simultaneous treatment with Gastril and digoxin

Contraindications

  • Known hypersensitivity to omeprazole
  • Suspicion of gastric ulcer and possibility of malignancy

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhea and headache
  • Gastrointestinal reactions like constipation, nausea/vomiting, flatulence, and abdominal pain
  • Other reactions including dry mouth, stomatitis, candidiasis, paraesthesia, dizziness, and somnolence
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms
  • Rare reactions like blurred vision, taste disturbance, peripheral edema, and increased sweating
  • Reports of hepatic failure, increases in liver enzymes, and interstitial nephritis

Pregnancy & Lactation

  • No adverse effects of omeprazole on pregnancy or on the health of the fetus/newborn child based on epidemiological studies
  • Use of omeprazole in pregnancy
  • No information available on the passage of omeprazole into breast milk or its effects on the neonate

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Gastril
  • Possible association of PPI therapy with increased risk for osteoporosis-related fractures
  • Noted cases of atrophic gastritis in patients treated long-term with Gastril
  • Potential for methotrexate toxicities when used concomitantly with PPIs

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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